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Industrial perspectives for personalized microneedles
Microneedles and, subsequently, microneedle arrays are emerging miniaturized medical devices for painless transdermal drug delivery. New and improved additive manufacturing methods enable novel microneedle designs to be realized for preclinical and clinical trial assessments. However, current litera...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442529/ https://www.ncbi.nlm.nih.gov/pubmed/37615014 http://dx.doi.org/10.3762/bjnano.14.70 |
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author | Baker-Sediako, Remmi Danae Richter, Benjamin Blaicher, Matthias Thiel, Michael Hermatschweiler, Martin |
author_facet | Baker-Sediako, Remmi Danae Richter, Benjamin Blaicher, Matthias Thiel, Michael Hermatschweiler, Martin |
author_sort | Baker-Sediako, Remmi Danae |
collection | PubMed |
description | Microneedles and, subsequently, microneedle arrays are emerging miniaturized medical devices for painless transdermal drug delivery. New and improved additive manufacturing methods enable novel microneedle designs to be realized for preclinical and clinical trial assessments. However, current literature reviews suggest that industrial manufacturers and researchers have focused their efforts on one-size-fits-all designs for transdermal drug delivery, regardless of patient demographic and injection site. In this perspective article, we briefly review current microneedle designs, microfabrication methods, and industrialization strategies. We also provide an outlook where microneedles may become personalized according to a patient’s demographic in order to increase drug delivery efficiency and reduce healing times for patient-centric care. |
format | Online Article Text |
id | pubmed-10442529 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-104425292023-08-23 Industrial perspectives for personalized microneedles Baker-Sediako, Remmi Danae Richter, Benjamin Blaicher, Matthias Thiel, Michael Hermatschweiler, Martin Beilstein J Nanotechnol Commentary Microneedles and, subsequently, microneedle arrays are emerging miniaturized medical devices for painless transdermal drug delivery. New and improved additive manufacturing methods enable novel microneedle designs to be realized for preclinical and clinical trial assessments. However, current literature reviews suggest that industrial manufacturers and researchers have focused their efforts on one-size-fits-all designs for transdermal drug delivery, regardless of patient demographic and injection site. In this perspective article, we briefly review current microneedle designs, microfabrication methods, and industrialization strategies. We also provide an outlook where microneedles may become personalized according to a patient’s demographic in order to increase drug delivery efficiency and reduce healing times for patient-centric care. Beilstein-Institut 2023-08-15 /pmc/articles/PMC10442529/ /pubmed/37615014 http://dx.doi.org/10.3762/bjnano.14.70 Text en Copyright © 2023, Baker-Sediako et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjnano/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material. |
spellingShingle | Commentary Baker-Sediako, Remmi Danae Richter, Benjamin Blaicher, Matthias Thiel, Michael Hermatschweiler, Martin Industrial perspectives for personalized microneedles |
title | Industrial perspectives for personalized microneedles |
title_full | Industrial perspectives for personalized microneedles |
title_fullStr | Industrial perspectives for personalized microneedles |
title_full_unstemmed | Industrial perspectives for personalized microneedles |
title_short | Industrial perspectives for personalized microneedles |
title_sort | industrial perspectives for personalized microneedles |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442529/ https://www.ncbi.nlm.nih.gov/pubmed/37615014 http://dx.doi.org/10.3762/bjnano.14.70 |
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