Cargando…

Industrial perspectives for personalized microneedles

Microneedles and, subsequently, microneedle arrays are emerging miniaturized medical devices for painless transdermal drug delivery. New and improved additive manufacturing methods enable novel microneedle designs to be realized for preclinical and clinical trial assessments. However, current litera...

Descripción completa

Detalles Bibliográficos
Autores principales: Baker-Sediako, Remmi Danae, Richter, Benjamin, Blaicher, Matthias, Thiel, Michael, Hermatschweiler, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442529/
https://www.ncbi.nlm.nih.gov/pubmed/37615014
http://dx.doi.org/10.3762/bjnano.14.70
_version_ 1785093620097875968
author Baker-Sediako, Remmi Danae
Richter, Benjamin
Blaicher, Matthias
Thiel, Michael
Hermatschweiler, Martin
author_facet Baker-Sediako, Remmi Danae
Richter, Benjamin
Blaicher, Matthias
Thiel, Michael
Hermatschweiler, Martin
author_sort Baker-Sediako, Remmi Danae
collection PubMed
description Microneedles and, subsequently, microneedle arrays are emerging miniaturized medical devices for painless transdermal drug delivery. New and improved additive manufacturing methods enable novel microneedle designs to be realized for preclinical and clinical trial assessments. However, current literature reviews suggest that industrial manufacturers and researchers have focused their efforts on one-size-fits-all designs for transdermal drug delivery, regardless of patient demographic and injection site. In this perspective article, we briefly review current microneedle designs, microfabrication methods, and industrialization strategies. We also provide an outlook where microneedles may become personalized according to a patient’s demographic in order to increase drug delivery efficiency and reduce healing times for patient-centric care.
format Online
Article
Text
id pubmed-10442529
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Beilstein-Institut
record_format MEDLINE/PubMed
spelling pubmed-104425292023-08-23 Industrial perspectives for personalized microneedles Baker-Sediako, Remmi Danae Richter, Benjamin Blaicher, Matthias Thiel, Michael Hermatschweiler, Martin Beilstein J Nanotechnol Commentary Microneedles and, subsequently, microneedle arrays are emerging miniaturized medical devices for painless transdermal drug delivery. New and improved additive manufacturing methods enable novel microneedle designs to be realized for preclinical and clinical trial assessments. However, current literature reviews suggest that industrial manufacturers and researchers have focused their efforts on one-size-fits-all designs for transdermal drug delivery, regardless of patient demographic and injection site. In this perspective article, we briefly review current microneedle designs, microfabrication methods, and industrialization strategies. We also provide an outlook where microneedles may become personalized according to a patient’s demographic in order to increase drug delivery efficiency and reduce healing times for patient-centric care. Beilstein-Institut 2023-08-15 /pmc/articles/PMC10442529/ /pubmed/37615014 http://dx.doi.org/10.3762/bjnano.14.70 Text en Copyright © 2023, Baker-Sediako et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjnano/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Commentary
Baker-Sediako, Remmi Danae
Richter, Benjamin
Blaicher, Matthias
Thiel, Michael
Hermatschweiler, Martin
Industrial perspectives for personalized microneedles
title Industrial perspectives for personalized microneedles
title_full Industrial perspectives for personalized microneedles
title_fullStr Industrial perspectives for personalized microneedles
title_full_unstemmed Industrial perspectives for personalized microneedles
title_short Industrial perspectives for personalized microneedles
title_sort industrial perspectives for personalized microneedles
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442529/
https://www.ncbi.nlm.nih.gov/pubmed/37615014
http://dx.doi.org/10.3762/bjnano.14.70
work_keys_str_mv AT bakersediakoremmidanae industrialperspectivesforpersonalizedmicroneedles
AT richterbenjamin industrialperspectivesforpersonalizedmicroneedles
AT blaichermatthias industrialperspectivesforpersonalizedmicroneedles
AT thielmichael industrialperspectivesforpersonalizedmicroneedles
AT hermatschweilermartin industrialperspectivesforpersonalizedmicroneedles