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Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury
The clinical sign of ataxia is related to several neurological diseases and is seen in conjunction with paresis in dogs with spinal cord injury (SCI). Endeavours to objectify canine spinal ataxia in SCI remain limited. The aim of this clinical study was to determine and quantify differences between...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442642/ https://www.ncbi.nlm.nih.gov/pubmed/37614460 http://dx.doi.org/10.3389/fvets.2023.1183755 |
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author | Sherif, Tamara Twele, Friederike Meller, Sebastian Müller-Anders, Alexandra Volk, Holger A. |
author_facet | Sherif, Tamara Twele, Friederike Meller, Sebastian Müller-Anders, Alexandra Volk, Holger A. |
author_sort | Sherif, Tamara |
collection | PubMed |
description | The clinical sign of ataxia is related to several neurological diseases and is seen in conjunction with paresis in dogs with spinal cord injury (SCI). Endeavours to objectify canine spinal ataxia in SCI remain limited. The aim of this clinical study was to determine and quantify differences between gait characteristics of ataxic dogs with thoracolumbar myelopathy and healthy control dogs using a computer-and treadmill-based gait analysis system. Five dogs with spinal ataxia and six healthy dogs underwent video-and computer-assisted gait analysis while walking on a four-ground reaction force plate treadmill system (maximum speed of 0.7 m/s). Spatio-temporal and kinetic gait characteristics regarding the dogs’ locomotion were analysed with a focus on the individual coefficient of variation (CV), as a potential measure for quantification of the level of ataxia. Ataxic dogs with thoracolumbar SCI showed no effect on symmetry indices but higher variability in spatio-temporal and kinetic gait parameters mainly in the pelvic, but also in the thoracic limbs. Double support phase of the individual limb was prolonged in SCI dogs at the cost of the single support and swing phase. Reduced peaks of ground reaction forces (GRF) could potentially be explained by reduction of muscle strength, as a strategy of avoiding falling by taking enthusiastic steps, or by alteration of the rhythmogenic spinal circuits between the pelvic and thoracic limb pattern generators. |
format | Online Article Text |
id | pubmed-10442642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104426422023-08-23 Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury Sherif, Tamara Twele, Friederike Meller, Sebastian Müller-Anders, Alexandra Volk, Holger A. Front Vet Sci Veterinary Science The clinical sign of ataxia is related to several neurological diseases and is seen in conjunction with paresis in dogs with spinal cord injury (SCI). Endeavours to objectify canine spinal ataxia in SCI remain limited. The aim of this clinical study was to determine and quantify differences between gait characteristics of ataxic dogs with thoracolumbar myelopathy and healthy control dogs using a computer-and treadmill-based gait analysis system. Five dogs with spinal ataxia and six healthy dogs underwent video-and computer-assisted gait analysis while walking on a four-ground reaction force plate treadmill system (maximum speed of 0.7 m/s). Spatio-temporal and kinetic gait characteristics regarding the dogs’ locomotion were analysed with a focus on the individual coefficient of variation (CV), as a potential measure for quantification of the level of ataxia. Ataxic dogs with thoracolumbar SCI showed no effect on symmetry indices but higher variability in spatio-temporal and kinetic gait parameters mainly in the pelvic, but also in the thoracic limbs. Double support phase of the individual limb was prolonged in SCI dogs at the cost of the single support and swing phase. Reduced peaks of ground reaction forces (GRF) could potentially be explained by reduction of muscle strength, as a strategy of avoiding falling by taking enthusiastic steps, or by alteration of the rhythmogenic spinal circuits between the pelvic and thoracic limb pattern generators. Frontiers Media S.A. 2023-08-08 /pmc/articles/PMC10442642/ /pubmed/37614460 http://dx.doi.org/10.3389/fvets.2023.1183755 Text en Copyright © 2023 Sherif, Twele, Meller, Müller-Anders and Volk. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Sherif, Tamara Twele, Friederike Meller, Sebastian Müller-Anders, Alexandra Volk, Holger A. Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury |
title | Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury |
title_full | Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury |
title_fullStr | Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury |
title_full_unstemmed | Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury |
title_short | Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury |
title_sort | quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442642/ https://www.ncbi.nlm.nih.gov/pubmed/37614460 http://dx.doi.org/10.3389/fvets.2023.1183755 |
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