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Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury

The clinical sign of ataxia is related to several neurological diseases and is seen in conjunction with paresis in dogs with spinal cord injury (SCI). Endeavours to objectify canine spinal ataxia in SCI remain limited. The aim of this clinical study was to determine and quantify differences between...

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Autores principales: Sherif, Tamara, Twele, Friederike, Meller, Sebastian, Müller-Anders, Alexandra, Volk, Holger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442642/
https://www.ncbi.nlm.nih.gov/pubmed/37614460
http://dx.doi.org/10.3389/fvets.2023.1183755
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author Sherif, Tamara
Twele, Friederike
Meller, Sebastian
Müller-Anders, Alexandra
Volk, Holger A.
author_facet Sherif, Tamara
Twele, Friederike
Meller, Sebastian
Müller-Anders, Alexandra
Volk, Holger A.
author_sort Sherif, Tamara
collection PubMed
description The clinical sign of ataxia is related to several neurological diseases and is seen in conjunction with paresis in dogs with spinal cord injury (SCI). Endeavours to objectify canine spinal ataxia in SCI remain limited. The aim of this clinical study was to determine and quantify differences between gait characteristics of ataxic dogs with thoracolumbar myelopathy and healthy control dogs using a computer-and treadmill-based gait analysis system. Five dogs with spinal ataxia and six healthy dogs underwent video-and computer-assisted gait analysis while walking on a four-ground reaction force plate treadmill system (maximum speed of 0.7 m/s). Spatio-temporal and kinetic gait characteristics regarding the dogs’ locomotion were analysed with a focus on the individual coefficient of variation (CV), as a potential measure for quantification of the level of ataxia. Ataxic dogs with thoracolumbar SCI showed no effect on symmetry indices but higher variability in spatio-temporal and kinetic gait parameters mainly in the pelvic, but also in the thoracic limbs. Double support phase of the individual limb was prolonged in SCI dogs at the cost of the single support and swing phase. Reduced peaks of ground reaction forces (GRF) could potentially be explained by reduction of muscle strength, as a strategy of avoiding falling by taking enthusiastic steps, or by alteration of the rhythmogenic spinal circuits between the pelvic and thoracic limb pattern generators.
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spelling pubmed-104426422023-08-23 Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury Sherif, Tamara Twele, Friederike Meller, Sebastian Müller-Anders, Alexandra Volk, Holger A. Front Vet Sci Veterinary Science The clinical sign of ataxia is related to several neurological diseases and is seen in conjunction with paresis in dogs with spinal cord injury (SCI). Endeavours to objectify canine spinal ataxia in SCI remain limited. The aim of this clinical study was to determine and quantify differences between gait characteristics of ataxic dogs with thoracolumbar myelopathy and healthy control dogs using a computer-and treadmill-based gait analysis system. Five dogs with spinal ataxia and six healthy dogs underwent video-and computer-assisted gait analysis while walking on a four-ground reaction force plate treadmill system (maximum speed of 0.7 m/s). Spatio-temporal and kinetic gait characteristics regarding the dogs’ locomotion were analysed with a focus on the individual coefficient of variation (CV), as a potential measure for quantification of the level of ataxia. Ataxic dogs with thoracolumbar SCI showed no effect on symmetry indices but higher variability in spatio-temporal and kinetic gait parameters mainly in the pelvic, but also in the thoracic limbs. Double support phase of the individual limb was prolonged in SCI dogs at the cost of the single support and swing phase. Reduced peaks of ground reaction forces (GRF) could potentially be explained by reduction of muscle strength, as a strategy of avoiding falling by taking enthusiastic steps, or by alteration of the rhythmogenic spinal circuits between the pelvic and thoracic limb pattern generators. Frontiers Media S.A. 2023-08-08 /pmc/articles/PMC10442642/ /pubmed/37614460 http://dx.doi.org/10.3389/fvets.2023.1183755 Text en Copyright © 2023 Sherif, Twele, Meller, Müller-Anders and Volk. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Sherif, Tamara
Twele, Friederike
Meller, Sebastian
Müller-Anders, Alexandra
Volk, Holger A.
Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury
title Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury
title_full Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury
title_fullStr Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury
title_full_unstemmed Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury
title_short Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury
title_sort quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442642/
https://www.ncbi.nlm.nih.gov/pubmed/37614460
http://dx.doi.org/10.3389/fvets.2023.1183755
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