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Cell type and sex specific mitochondrial phenotypes in iPSC derived models of Alzheimer’s disease

INTRODUCTION: Mitochondrial dysfunction is observed in Alzheimer’s disease (AD). Altered mitochondrial respiration, cytochrome oxidase (COX) Vmax, and mitophagy are observed in human subjects and animal models of AD. Models derived from induced pluripotent stem cells (iPSCs) may not recapitulate the...

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Detalles Bibliográficos
Autores principales:	Flannagan, Kaitlin, Stopperan, Julia A., Hauger, Brittany M., Troutwine, Benjamin R., Lysaker, Colton R., Strope, Taylor A., Csikos Drummond, Vivien, Gilmore, Caleb A., Swerdlow, Natalie A., Draper, Julia M., Gouvion, Cynthia M., Vivian, Jay L., Haeri, Mohammad, Swerdlow, Russell H., Wilkins, Heather M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442646/ https://www.ncbi.nlm.nih.gov/pubmed/37614699 http://dx.doi.org/10.3389/fnmol.2023.1201015

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