Cargando…

Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report

Primary plasma cell leukemia (pPCL) is a rare and aggressive form of plasma cell disorder, which accounts for ~70% of all PCL. Survival of pPCL remains poor, and is related with early mortality. There is no standard therapy for patients with pPCL. In the present study, a 26-year-old man who was diag...

Descripción completa

Detalles Bibliográficos
Autores principales: Fu, Weijia, Huang, Aijie, Luo, Yanrong, Liu, Miaomiao, Tang, Gusheng, Yang, Jianmin, Ni, Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442742/
https://www.ncbi.nlm.nih.gov/pubmed/37614372
http://dx.doi.org/10.3892/mco.2023.2671
_version_ 1785093669179621376
author Fu, Weijia
Huang, Aijie
Luo, Yanrong
Liu, Miaomiao
Tang, Gusheng
Yang, Jianmin
Ni, Xiong
author_facet Fu, Weijia
Huang, Aijie
Luo, Yanrong
Liu, Miaomiao
Tang, Gusheng
Yang, Jianmin
Ni, Xiong
author_sort Fu, Weijia
collection PubMed
description Primary plasma cell leukemia (pPCL) is a rare and aggressive form of plasma cell disorder, which accounts for ~70% of all PCL. Survival of pPCL remains poor, and is related with early mortality. There is no standard therapy for patients with pPCL. In the present study, a 26-year-old man who was diagnosed with pPCL was reported. The patient achieved stringent complete remission to the successful treatment of intensive chemotherapy combined with sequential autologous and allogeneic stem cell transplantation (SCT) followed by maintenance therapy with oral administration of ixazomib, thalidomide and dexamethasone (IRD regimen). Development of complex treatment algorithms that combine novel agents, SCT and post-transplantation remission strategies may translate into survival in patients with pPCL.
format Online
Article
Text
id pubmed-10442742
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-104427422023-08-23 Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report Fu, Weijia Huang, Aijie Luo, Yanrong Liu, Miaomiao Tang, Gusheng Yang, Jianmin Ni, Xiong Mol Clin Oncol Case Report Primary plasma cell leukemia (pPCL) is a rare and aggressive form of plasma cell disorder, which accounts for ~70% of all PCL. Survival of pPCL remains poor, and is related with early mortality. There is no standard therapy for patients with pPCL. In the present study, a 26-year-old man who was diagnosed with pPCL was reported. The patient achieved stringent complete remission to the successful treatment of intensive chemotherapy combined with sequential autologous and allogeneic stem cell transplantation (SCT) followed by maintenance therapy with oral administration of ixazomib, thalidomide and dexamethasone (IRD regimen). Development of complex treatment algorithms that combine novel agents, SCT and post-transplantation remission strategies may translate into survival in patients with pPCL. D.A. Spandidos 2023-08-02 /pmc/articles/PMC10442742/ /pubmed/37614372 http://dx.doi.org/10.3892/mco.2023.2671 Text en Copyright: © Fu et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Case Report
Fu, Weijia
Huang, Aijie
Luo, Yanrong
Liu, Miaomiao
Tang, Gusheng
Yang, Jianmin
Ni, Xiong
Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report
title Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report
title_full Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report
title_fullStr Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report
title_full_unstemmed Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report
title_short Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report
title_sort sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442742/
https://www.ncbi.nlm.nih.gov/pubmed/37614372
http://dx.doi.org/10.3892/mco.2023.2671
work_keys_str_mv AT fuweijia sequentialautologousandallogeneicstemcelltransplantationfortreatmentofprimaryplasmacellleukemiaacasereport
AT huangaijie sequentialautologousandallogeneicstemcelltransplantationfortreatmentofprimaryplasmacellleukemiaacasereport
AT luoyanrong sequentialautologousandallogeneicstemcelltransplantationfortreatmentofprimaryplasmacellleukemiaacasereport
AT liumiaomiao sequentialautologousandallogeneicstemcelltransplantationfortreatmentofprimaryplasmacellleukemiaacasereport
AT tanggusheng sequentialautologousandallogeneicstemcelltransplantationfortreatmentofprimaryplasmacellleukemiaacasereport
AT yangjianmin sequentialautologousandallogeneicstemcelltransplantationfortreatmentofprimaryplasmacellleukemiaacasereport
AT nixiong sequentialautologousandallogeneicstemcelltransplantationfortreatmentofprimaryplasmacellleukemiaacasereport