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Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report
Primary plasma cell leukemia (pPCL) is a rare and aggressive form of plasma cell disorder, which accounts for ~70% of all PCL. Survival of pPCL remains poor, and is related with early mortality. There is no standard therapy for patients with pPCL. In the present study, a 26-year-old man who was diag...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442742/ https://www.ncbi.nlm.nih.gov/pubmed/37614372 http://dx.doi.org/10.3892/mco.2023.2671 |
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author | Fu, Weijia Huang, Aijie Luo, Yanrong Liu, Miaomiao Tang, Gusheng Yang, Jianmin Ni, Xiong |
author_facet | Fu, Weijia Huang, Aijie Luo, Yanrong Liu, Miaomiao Tang, Gusheng Yang, Jianmin Ni, Xiong |
author_sort | Fu, Weijia |
collection | PubMed |
description | Primary plasma cell leukemia (pPCL) is a rare and aggressive form of plasma cell disorder, which accounts for ~70% of all PCL. Survival of pPCL remains poor, and is related with early mortality. There is no standard therapy for patients with pPCL. In the present study, a 26-year-old man who was diagnosed with pPCL was reported. The patient achieved stringent complete remission to the successful treatment of intensive chemotherapy combined with sequential autologous and allogeneic stem cell transplantation (SCT) followed by maintenance therapy with oral administration of ixazomib, thalidomide and dexamethasone (IRD regimen). Development of complex treatment algorithms that combine novel agents, SCT and post-transplantation remission strategies may translate into survival in patients with pPCL. |
format | Online Article Text |
id | pubmed-10442742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-104427422023-08-23 Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report Fu, Weijia Huang, Aijie Luo, Yanrong Liu, Miaomiao Tang, Gusheng Yang, Jianmin Ni, Xiong Mol Clin Oncol Case Report Primary plasma cell leukemia (pPCL) is a rare and aggressive form of plasma cell disorder, which accounts for ~70% of all PCL. Survival of pPCL remains poor, and is related with early mortality. There is no standard therapy for patients with pPCL. In the present study, a 26-year-old man who was diagnosed with pPCL was reported. The patient achieved stringent complete remission to the successful treatment of intensive chemotherapy combined with sequential autologous and allogeneic stem cell transplantation (SCT) followed by maintenance therapy with oral administration of ixazomib, thalidomide and dexamethasone (IRD regimen). Development of complex treatment algorithms that combine novel agents, SCT and post-transplantation remission strategies may translate into survival in patients with pPCL. D.A. Spandidos 2023-08-02 /pmc/articles/PMC10442742/ /pubmed/37614372 http://dx.doi.org/10.3892/mco.2023.2671 Text en Copyright: © Fu et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Case Report Fu, Weijia Huang, Aijie Luo, Yanrong Liu, Miaomiao Tang, Gusheng Yang, Jianmin Ni, Xiong Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report |
title | Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report |
title_full | Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report |
title_fullStr | Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report |
title_full_unstemmed | Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report |
title_short | Sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: A case report |
title_sort | sequential autologous and allogeneic stem cell transplantation for treatment of primary plasma cell leukemia: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442742/ https://www.ncbi.nlm.nih.gov/pubmed/37614372 http://dx.doi.org/10.3892/mco.2023.2671 |
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