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Current status and prospects of GREM1 research in cancer (Review)

GREM1 is a secreted protein that antagonizes bone morphogenetic proteins (BMPs) and participates in critical biological processes, including embryonic development, organogenesis and tissue differentiation. Gremlin 1 (GREM1) is also an inhibitor of TGF-β and a ligand for vascular endothelial growth f...

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Autores principales: Zhu, Dantong, Zhao, Dong, Wang, Naixue, Cai, Fei, Jiang, Mingzhe, Zheng, Zhendong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442762/
https://www.ncbi.nlm.nih.gov/pubmed/37614374
http://dx.doi.org/10.3892/mco.2023.2665
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author Zhu, Dantong
Zhao, Dong
Wang, Naixue
Cai, Fei
Jiang, Mingzhe
Zheng, Zhendong
author_facet Zhu, Dantong
Zhao, Dong
Wang, Naixue
Cai, Fei
Jiang, Mingzhe
Zheng, Zhendong
author_sort Zhu, Dantong
collection PubMed
description GREM1 is a secreted protein that antagonizes bone morphogenetic proteins (BMPs) and participates in critical biological processes, including embryonic development, organogenesis and tissue differentiation. Gremlin 1 (GREM1) is also an inhibitor of TGF-β and a ligand for vascular endothelial growth factor receptor 2. In addition, GREM1 can induce cells, participate in the process of epithelial-mesenchymal transition, and then participate in tumor development. GREM1 has a variety of biological functions and can participate in the malignant progression of a variety of tumors through the BMP signaling pathway. GREM1 also can inhibit TGF-β in some tumors, thereby inhibiting tumors, and its involvement in tumor development varies in different types of cancer. The present review examines the role and function of GREM1 in tumors. GREM1 is expressed in a variety of tumor types. GREM1 expression can affect the epithelial-mesenchymal transformation of tumor cells. GREM1 has been studied in breast and colon cancer, and its potential role is to promote cancer. However, in pancreatic cancer, which was found to act differently from other cancer types, overexpression of GREM1 inhibits tumor metastasis. The present review suggests that GREM1 can be a diagnostic and prognostic indicator. In future studies, the study of GREM1 based on single-cell sequencing technology will further clarify its role and function in tumors.
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spelling pubmed-104427622023-08-23 Current status and prospects of GREM1 research in cancer (Review) Zhu, Dantong Zhao, Dong Wang, Naixue Cai, Fei Jiang, Mingzhe Zheng, Zhendong Mol Clin Oncol Review GREM1 is a secreted protein that antagonizes bone morphogenetic proteins (BMPs) and participates in critical biological processes, including embryonic development, organogenesis and tissue differentiation. Gremlin 1 (GREM1) is also an inhibitor of TGF-β and a ligand for vascular endothelial growth factor receptor 2. In addition, GREM1 can induce cells, participate in the process of epithelial-mesenchymal transition, and then participate in tumor development. GREM1 has a variety of biological functions and can participate in the malignant progression of a variety of tumors through the BMP signaling pathway. GREM1 also can inhibit TGF-β in some tumors, thereby inhibiting tumors, and its involvement in tumor development varies in different types of cancer. The present review examines the role and function of GREM1 in tumors. GREM1 is expressed in a variety of tumor types. GREM1 expression can affect the epithelial-mesenchymal transformation of tumor cells. GREM1 has been studied in breast and colon cancer, and its potential role is to promote cancer. However, in pancreatic cancer, which was found to act differently from other cancer types, overexpression of GREM1 inhibits tumor metastasis. The present review suggests that GREM1 can be a diagnostic and prognostic indicator. In future studies, the study of GREM1 based on single-cell sequencing technology will further clarify its role and function in tumors. D.A. Spandidos 2023-07-19 /pmc/articles/PMC10442762/ /pubmed/37614374 http://dx.doi.org/10.3892/mco.2023.2665 Text en Copyright: © Zhu et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Zhu, Dantong
Zhao, Dong
Wang, Naixue
Cai, Fei
Jiang, Mingzhe
Zheng, Zhendong
Current status and prospects of GREM1 research in cancer (Review)
title Current status and prospects of GREM1 research in cancer (Review)
title_full Current status and prospects of GREM1 research in cancer (Review)
title_fullStr Current status and prospects of GREM1 research in cancer (Review)
title_full_unstemmed Current status and prospects of GREM1 research in cancer (Review)
title_short Current status and prospects of GREM1 research in cancer (Review)
title_sort current status and prospects of grem1 research in cancer (review)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442762/
https://www.ncbi.nlm.nih.gov/pubmed/37614374
http://dx.doi.org/10.3892/mco.2023.2665
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