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Association between weight-adjusted-waist index and female infertility: a population-based study

AIMS: Obesity is detrimental to infertility. The association between weight-adjusted-waist index (WWI, a recently developed adiposity indicator) and infertility has not previously been confirmed. METHODS: The data for this study were obtained from the National Health and Nutrition Examination Survey...

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Autores principales: Wen, Zujun, Li, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442810/
https://www.ncbi.nlm.nih.gov/pubmed/37614708
http://dx.doi.org/10.3389/fendo.2023.1175394
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author Wen, Zujun
Li, Xiang
author_facet Wen, Zujun
Li, Xiang
author_sort Wen, Zujun
collection PubMed
description AIMS: Obesity is detrimental to infertility. The association between weight-adjusted-waist index (WWI, a recently developed adiposity indicator) and infertility has not previously been confirmed. METHODS: The data for this study were obtained from the National Health and Nutrition Examination Survey (NHANES) 2013-2018. Each participant’s WWI was calculated as their waist circumference in centimeters by the square root of weight in kilograms. Multivariable logistic regression and generalized additive model were utilized to investigate the relationship between WWI with infertility. We used smoothed curve fitting to explore the non-linear relationship. Subgroup analysis and interaction tests were also conducted. RESULTS: A total of 3,526 participants with ages from18 to 45 were enrolled, 364 of whom were infertile. With the higher WWI, infertility was more prevalent (OR = 1.42, 95% CI: 1.22-1.65), and this association was still consistent in subgroups (all P for interaction> 0.05). Smoothed curve fitting showed a positive non-linear relationship between WWI and infertility. Furthermore, we discovered that WWI had a stronger connection with the risk of infertility than other markers of obesity including WC, body mass index (BMI) and a body shape index (ABSI). CONCLUSIONS: Weight-adjusted-waist index levels were positively linked to an increased risk of infertility in American females and showed a stronger association than other markers of obesity. Our research indicated WWI could help identify women with infertility, and managing obesity as determined by WWI may help to reduce the risk of infertility.
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spelling pubmed-104428102023-08-23 Association between weight-adjusted-waist index and female infertility: a population-based study Wen, Zujun Li, Xiang Front Endocrinol (Lausanne) Endocrinology AIMS: Obesity is detrimental to infertility. The association between weight-adjusted-waist index (WWI, a recently developed adiposity indicator) and infertility has not previously been confirmed. METHODS: The data for this study were obtained from the National Health and Nutrition Examination Survey (NHANES) 2013-2018. Each participant’s WWI was calculated as their waist circumference in centimeters by the square root of weight in kilograms. Multivariable logistic regression and generalized additive model were utilized to investigate the relationship between WWI with infertility. We used smoothed curve fitting to explore the non-linear relationship. Subgroup analysis and interaction tests were also conducted. RESULTS: A total of 3,526 participants with ages from18 to 45 were enrolled, 364 of whom were infertile. With the higher WWI, infertility was more prevalent (OR = 1.42, 95% CI: 1.22-1.65), and this association was still consistent in subgroups (all P for interaction> 0.05). Smoothed curve fitting showed a positive non-linear relationship between WWI and infertility. Furthermore, we discovered that WWI had a stronger connection with the risk of infertility than other markers of obesity including WC, body mass index (BMI) and a body shape index (ABSI). CONCLUSIONS: Weight-adjusted-waist index levels were positively linked to an increased risk of infertility in American females and showed a stronger association than other markers of obesity. Our research indicated WWI could help identify women with infertility, and managing obesity as determined by WWI may help to reduce the risk of infertility. Frontiers Media S.A. 2023-08-08 /pmc/articles/PMC10442810/ /pubmed/37614708 http://dx.doi.org/10.3389/fendo.2023.1175394 Text en Copyright © 2023 Wen and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Wen, Zujun
Li, Xiang
Association between weight-adjusted-waist index and female infertility: a population-based study
title Association between weight-adjusted-waist index and female infertility: a population-based study
title_full Association between weight-adjusted-waist index and female infertility: a population-based study
title_fullStr Association between weight-adjusted-waist index and female infertility: a population-based study
title_full_unstemmed Association between weight-adjusted-waist index and female infertility: a population-based study
title_short Association between weight-adjusted-waist index and female infertility: a population-based study
title_sort association between weight-adjusted-waist index and female infertility: a population-based study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442810/
https://www.ncbi.nlm.nih.gov/pubmed/37614708
http://dx.doi.org/10.3389/fendo.2023.1175394
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