Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators

[Image: see text] Pharmacological activation of the activating transcription factor 6 (ATF6) arm of the unfolded protein response (UPR) has proven useful for ameliorating proteostasis deficiencies in cellular and mouse models of numerous etiologically diverse diseases. Previous high-throughput scree...

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Detalles Bibliográficos
Autores principales: Kline, Gabriel M., Paxman, Ryan J., Lin, Chung-Yon, Madrazo, Nicole, Yoon, Leonard, Grandjean, Julia M. D., Lee, Kyunga, Nugroho, Karina, Powers, Evan T., Wiseman, R. Luke, Kelly, Jeffery W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442855/
https://www.ncbi.nlm.nih.gov/pubmed/37523656
http://dx.doi.org/10.1021/acschembio.3c00042

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