Cellular Uptake of a Fluorescent Ligand Reveals Ghrelin O-Acyltransferase Interacts with Extracellular Peptides and Exhibits Unexpected Localization for a Secretory Pathway Enzyme

[Image: see text] Ghrelin O-acyltransferase (GOAT) plays a central role in the maturation and activation of the peptide hormone ghrelin, which performs a wide range of endocrinological signaling roles. Using a tight-binding fluorescent ghrelin-derived peptide designed for high selectivity for GOAT o...

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Detalles Bibliográficos
Autores principales: Campaña, Maria B., Davis, Tasha R., Novak, Sadie X., Cleverdon, Elizabeth R., Bates, Michael, Krishnan, Nikhila, Curtis, Erin R., Childs, Marina D., Pierce, Mariah R., Morales-Rodriguez, Yasandra, Sieburg, Michelle A., Hehnly, Heidi, Luyt, Leonard G., Hougland, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442857/
https://www.ncbi.nlm.nih.gov/pubmed/37494676
http://dx.doi.org/10.1021/acschembio.3c00334

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