Synthesis of Dolutegravir Exploiting Continuous Flow Chemistry

[Image: see text] An efficient continuous flow process for the synthesis of dolutegravir, an active pharmaceutical ingredient (API) for HIV treatment, was investigated. The synthetic procedure starts from a readily available benzyl-protected pyran via six chemical transformations using continuous fl...

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Detalles Bibliográficos
Autores principales: Nqeketo, Sinazo, Watts, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442919/
https://www.ncbi.nlm.nih.gov/pubmed/37552841
http://dx.doi.org/10.1021/acs.joc.3c01365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442919/
https://www.ncbi.nlm.nih.gov/pubmed/37552841
http://dx.doi.org/10.1021/acs.joc.3c01365

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