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Synthesis of Dolutegravir Exploiting Continuous Flow Chemistry
[Image: see text] An efficient continuous flow process for the synthesis of dolutegravir, an active pharmaceutical ingredient (API) for HIV treatment, was investigated. The synthetic procedure starts from a readily available benzyl-protected pyran via six chemical transformations using continuous fl...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442919/ https://www.ncbi.nlm.nih.gov/pubmed/37552841 http://dx.doi.org/10.1021/acs.joc.3c01365 |