Identifying Antisense Oligonucleotides to Disrupt Small RNA Regulated Antibiotic Resistance via a Cell-Free Transcription–Translation Platform

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[Image: see text] Bacterial small RNAs (sRNAs) regulate many important physiological processes in cells, including antibiotic resistance and virulence genes, through base-pairing interactions with mRNAs. Antisense oligonucleotides (ASOs) have great potential as therapeutics against bacterial pathoge...

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Detalles Bibliográficos
Autores principales: Tsai, Min Jen, Zambrano, Raphael Angelo I., Susas, Jeremiah Lyn, Silva, Lizette, Takahashi, Melissa K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443041/
https://www.ncbi.nlm.nih.gov/pubmed/37540186
http://dx.doi.org/10.1021/acssynbio.3c00245
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