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Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes
Paraneoplastic antibody syndromes result from the anti-tumor antibody response against normal antigens ectopically expressed by tumor cells. Although this antibody response plays an important role in helping clear a nascent or established tumor, the engagement of antigens expressed in healthy tissue...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443237/ https://www.ncbi.nlm.nih.gov/pubmed/37606434 http://dx.doi.org/10.3390/antib12030050 |
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author | Chiu, Daniel Rhee, John Gonzalez Castro, L. Nicolas |
author_facet | Chiu, Daniel Rhee, John Gonzalez Castro, L. Nicolas |
author_sort | Chiu, Daniel |
collection | PubMed |
description | Paraneoplastic antibody syndromes result from the anti-tumor antibody response against normal antigens ectopically expressed by tumor cells. Although this antibody response plays an important role in helping clear a nascent or established tumor, the engagement of antigens expressed in healthy tissues can lead to complex clinical syndromes with challenging diagnosis and management. The majority of known paraneoplastic antibody syndromes have been found to affect the central and peripheral nervous system. The present review provides an update on the pathophysiology of paraneoplastic neurologic syndromes, as well as recommendations for their diagnosis and treatment. |
format | Online Article Text |
id | pubmed-10443237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104432372023-08-23 Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes Chiu, Daniel Rhee, John Gonzalez Castro, L. Nicolas Antibodies (Basel) Review Paraneoplastic antibody syndromes result from the anti-tumor antibody response against normal antigens ectopically expressed by tumor cells. Although this antibody response plays an important role in helping clear a nascent or established tumor, the engagement of antigens expressed in healthy tissues can lead to complex clinical syndromes with challenging diagnosis and management. The majority of known paraneoplastic antibody syndromes have been found to affect the central and peripheral nervous system. The present review provides an update on the pathophysiology of paraneoplastic neurologic syndromes, as well as recommendations for their diagnosis and treatment. MDPI 2023-07-31 /pmc/articles/PMC10443237/ /pubmed/37606434 http://dx.doi.org/10.3390/antib12030050 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chiu, Daniel Rhee, John Gonzalez Castro, L. Nicolas Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes |
title | Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes |
title_full | Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes |
title_fullStr | Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes |
title_full_unstemmed | Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes |
title_short | Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes |
title_sort | diagnosis and treatment of paraneoplastic neurologic syndromes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443237/ https://www.ncbi.nlm.nih.gov/pubmed/37606434 http://dx.doi.org/10.3390/antib12030050 |
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