Cargando…

Hemodynamic, Oxygenation and Lymphocyte Parameters Predict COVID-19 Mortality

The mortality of COVID-19 patients has left the world devastated. Many scoring systems have been developed to predict the mortality of COVID-19 patients, but several scoring components cannot be carried out in limited health facilities. Herein, the authors attempted to create a new and easy scoring...

Descripción completa

Detalles Bibliográficos
Autores principales: Windradi, Choirina, Asmarawati, Tri Pudy, Rosyid, Alfian Nur, Marfiani, Erika, Mahdi, Bagus Aulia, Martani, Okla Sekar, Giarena, Giarena, Agustin, Esthiningrum Dewi, Rosandy, Milanitalia Gadys
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443272/
https://www.ncbi.nlm.nih.gov/pubmed/37606387
http://dx.doi.org/10.3390/pathophysiology30030025
_version_ 1785093789249961984
author Windradi, Choirina
Asmarawati, Tri Pudy
Rosyid, Alfian Nur
Marfiani, Erika
Mahdi, Bagus Aulia
Martani, Okla Sekar
Giarena, Giarena
Agustin, Esthiningrum Dewi
Rosandy, Milanitalia Gadys
author_facet Windradi, Choirina
Asmarawati, Tri Pudy
Rosyid, Alfian Nur
Marfiani, Erika
Mahdi, Bagus Aulia
Martani, Okla Sekar
Giarena, Giarena
Agustin, Esthiningrum Dewi
Rosandy, Milanitalia Gadys
author_sort Windradi, Choirina
collection PubMed
description The mortality of COVID-19 patients has left the world devastated. Many scoring systems have been developed to predict the mortality of COVID-19 patients, but several scoring components cannot be carried out in limited health facilities. Herein, the authors attempted to create a new and easy scoring system involving mean arterial pressure (MAP), PF Ratio, or SF ratio-respiration rate (SF Ratio-R), and lymphocyte absolute, which were abbreviated as MPL or MSLR functioning, as a predictive scoring system for mortality within 30 days for COVID-19 patients. Of 132 patients with COVID-19 hospitalized between March and November 2021, we followed up on 96 patients. We present bivariate and multivariate analyses as well as the area under the curve (AUC) and Kaplan–Meier charts. From 96 patients, we obtained an MPL score of 3 points: MAP < 75 mmHg, PF Ratio < 200, and lymphocyte absolute < 1500/µL, whereas the MSLR score was 6 points: MAP < 75 mmHg, SF Ratio < 200, lymphocyte absolute < 1500/µL, and respiration rate 24/min. The MPL cut-off point is 2, while the MSLR is 4. MPL and MSLR have the same sensitivity (79.1%) and specificity (75.5%). The AUC value of MPL vs. MSLR was 0.802 vs. 0.807. The MPL ≥ 2 and MSLR ≥ 4 revealed similar predictions for survival within 30 days (p < 0.05). Conclusion: MPL and MSLR scores are potential predictors of mortality in COVID-19 patients within 30 days in a resource-limited country.
format Online
Article
Text
id pubmed-10443272
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104432722023-08-23 Hemodynamic, Oxygenation and Lymphocyte Parameters Predict COVID-19 Mortality Windradi, Choirina Asmarawati, Tri Pudy Rosyid, Alfian Nur Marfiani, Erika Mahdi, Bagus Aulia Martani, Okla Sekar Giarena, Giarena Agustin, Esthiningrum Dewi Rosandy, Milanitalia Gadys Pathophysiology Article The mortality of COVID-19 patients has left the world devastated. Many scoring systems have been developed to predict the mortality of COVID-19 patients, but several scoring components cannot be carried out in limited health facilities. Herein, the authors attempted to create a new and easy scoring system involving mean arterial pressure (MAP), PF Ratio, or SF ratio-respiration rate (SF Ratio-R), and lymphocyte absolute, which were abbreviated as MPL or MSLR functioning, as a predictive scoring system for mortality within 30 days for COVID-19 patients. Of 132 patients with COVID-19 hospitalized between March and November 2021, we followed up on 96 patients. We present bivariate and multivariate analyses as well as the area under the curve (AUC) and Kaplan–Meier charts. From 96 patients, we obtained an MPL score of 3 points: MAP < 75 mmHg, PF Ratio < 200, and lymphocyte absolute < 1500/µL, whereas the MSLR score was 6 points: MAP < 75 mmHg, SF Ratio < 200, lymphocyte absolute < 1500/µL, and respiration rate 24/min. The MPL cut-off point is 2, while the MSLR is 4. MPL and MSLR have the same sensitivity (79.1%) and specificity (75.5%). The AUC value of MPL vs. MSLR was 0.802 vs. 0.807. The MPL ≥ 2 and MSLR ≥ 4 revealed similar predictions for survival within 30 days (p < 0.05). Conclusion: MPL and MSLR scores are potential predictors of mortality in COVID-19 patients within 30 days in a resource-limited country. MDPI 2023-08-02 /pmc/articles/PMC10443272/ /pubmed/37606387 http://dx.doi.org/10.3390/pathophysiology30030025 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Windradi, Choirina
Asmarawati, Tri Pudy
Rosyid, Alfian Nur
Marfiani, Erika
Mahdi, Bagus Aulia
Martani, Okla Sekar
Giarena, Giarena
Agustin, Esthiningrum Dewi
Rosandy, Milanitalia Gadys
Hemodynamic, Oxygenation and Lymphocyte Parameters Predict COVID-19 Mortality
title Hemodynamic, Oxygenation and Lymphocyte Parameters Predict COVID-19 Mortality
title_full Hemodynamic, Oxygenation and Lymphocyte Parameters Predict COVID-19 Mortality
title_fullStr Hemodynamic, Oxygenation and Lymphocyte Parameters Predict COVID-19 Mortality
title_full_unstemmed Hemodynamic, Oxygenation and Lymphocyte Parameters Predict COVID-19 Mortality
title_short Hemodynamic, Oxygenation and Lymphocyte Parameters Predict COVID-19 Mortality
title_sort hemodynamic, oxygenation and lymphocyte parameters predict covid-19 mortality
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443272/
https://www.ncbi.nlm.nih.gov/pubmed/37606387
http://dx.doi.org/10.3390/pathophysiology30030025
work_keys_str_mv AT windradichoirina hemodynamicoxygenationandlymphocyteparameterspredictcovid19mortality
AT asmarawatitripudy hemodynamicoxygenationandlymphocyteparameterspredictcovid19mortality
AT rosyidalfiannur hemodynamicoxygenationandlymphocyteparameterspredictcovid19mortality
AT marfianierika hemodynamicoxygenationandlymphocyteparameterspredictcovid19mortality
AT mahdibagusaulia hemodynamicoxygenationandlymphocyteparameterspredictcovid19mortality
AT martanioklasekar hemodynamicoxygenationandlymphocyteparameterspredictcovid19mortality
AT giarenagiarena hemodynamicoxygenationandlymphocyteparameterspredictcovid19mortality
AT agustinesthiningrumdewi hemodynamicoxygenationandlymphocyteparameterspredictcovid19mortality
AT rosandymilanitaliagadys hemodynamicoxygenationandlymphocyteparameterspredictcovid19mortality