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Modulation of a conformational ensemble by a small molecule that inhibits key protein–protein interactions involved in cell adhesion
Small molecules that regulate protein–protein interactions can be valuable drugs; however, the development of such small molecules is challenging as the molecule must interfere with an interaction that often involves a large surface area. Herein, we propose that modulating the conformational ensembl...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443342/ https://www.ncbi.nlm.nih.gov/pubmed/37531208 http://dx.doi.org/10.1002/pro.4744 |