The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections

Emerging evidence highlights the multifaceted roles of the RNA epitranscriptome during viral infections. By modulating the modification landscape of viral and host RNAs, viruses enhance their propagation and elude host surveillance mechanisms. Here, we discuss how specific RNA modifications, in eith...

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Autores principales: Ribeiro, Diana Roberta, Nunes, Alexandre, Ribeiro, Daniela, Soares, Ana Raquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443596/
https://www.ncbi.nlm.nih.gov/pubmed/37614818
http://dx.doi.org/10.3389/fgene.2023.1245683
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author Ribeiro, Diana Roberta
Nunes, Alexandre
Ribeiro, Daniela
Soares, Ana Raquel
author_facet Ribeiro, Diana Roberta
Nunes, Alexandre
Ribeiro, Daniela
Soares, Ana Raquel
author_sort Ribeiro, Diana Roberta
collection PubMed
description Emerging evidence highlights the multifaceted roles of the RNA epitranscriptome during viral infections. By modulating the modification landscape of viral and host RNAs, viruses enhance their propagation and elude host surveillance mechanisms. Here, we discuss how specific RNA modifications, in either host or viral RNA molecules, impact the virus-life cycle and host antiviral responses, highlighting the potential of targeting the RNA epitranscriptome for novel antiviral therapies.
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spelling pubmed-104435962023-08-23 The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections Ribeiro, Diana Roberta Nunes, Alexandre Ribeiro, Daniela Soares, Ana Raquel Front Genet Genetics Emerging evidence highlights the multifaceted roles of the RNA epitranscriptome during viral infections. By modulating the modification landscape of viral and host RNAs, viruses enhance their propagation and elude host surveillance mechanisms. Here, we discuss how specific RNA modifications, in either host or viral RNA molecules, impact the virus-life cycle and host antiviral responses, highlighting the potential of targeting the RNA epitranscriptome for novel antiviral therapies. Frontiers Media S.A. 2023-08-01 /pmc/articles/PMC10443596/ /pubmed/37614818 http://dx.doi.org/10.3389/fgene.2023.1245683 Text en Copyright © 2023 Ribeiro, Nunes, Ribeiro and Soares. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Ribeiro, Diana Roberta
Nunes, Alexandre
Ribeiro, Daniela
Soares, Ana Raquel
The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections
title The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections
title_full The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections
title_fullStr The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections
title_full_unstemmed The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections
title_short The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections
title_sort hidden rna code: implications of the rna epitranscriptome in the context of viral infections
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443596/
https://www.ncbi.nlm.nih.gov/pubmed/37614818
http://dx.doi.org/10.3389/fgene.2023.1245683
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