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Prognostic Nutritional Index (PNI) as a Predictor in Patients with Metabolic Syndrome and Heart Failure
PURPOSE: There is a lack of research on nutritional status and poor prognosis in patients with metabolic syndrome and heart failure. This study evaluated the relationship between nutritional status as defined by the PNI and adverse outcomes in patients with metabolic syndrome and heart failure. METH...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443633/ https://www.ncbi.nlm.nih.gov/pubmed/37614379 http://dx.doi.org/10.2147/DMSO.S420924 |
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author | Zhang, Xuehe Zhang, Jixin Liu, Fen Li, Wenling Zhang, Tong Fang, Binbin Zhang, Zhiyang Xie, Qian Yang, Yining Li, Xiaomei |
author_facet | Zhang, Xuehe Zhang, Jixin Liu, Fen Li, Wenling Zhang, Tong Fang, Binbin Zhang, Zhiyang Xie, Qian Yang, Yining Li, Xiaomei |
author_sort | Zhang, Xuehe |
collection | PubMed |
description | PURPOSE: There is a lack of research on nutritional status and poor prognosis in patients with metabolic syndrome and heart failure. This study evaluated the relationship between nutritional status as defined by the PNI and adverse outcomes in patients with metabolic syndrome and heart failure. METHODS: A total of 1048 heart failure patients with metabolic syndrome admitted to the Heart Center of the First Affiliated Hospital of Xinjiang Medical University from January 2015 to December 2019 were consecutively. PNI was used to assess their nutritional status. RESULTS: A total of 51.0% of the patients were in the nonmalnutrition group (PNI≥45), 27.9% were in the mild malnutrition group (40≤PNI<45), and 21.1% of patients were in the malnutrition group (PNI<40). At 36 months of follow-up, after adjusting for other confounding factors, malnutrition (PNI<40) was independently associated with all-cause death (HR: 1.787, 95% CI: 1.451–2.201, P<0.001) and cardiovascular death (HR: 1.837, 95% CI: 1.467–2.301, P<0.001). PNI showed additional prognostic predictive value when included in the established risk factor model, both for all-cause death (AUC: 0.620, 95% CI: 0.579–0.661, P<0.001) and cardiovascular death (AUC: 0.596, 95% CI: 0.555–0.636, P<0.001). CONCLUSION: In patients with metabolic syndrome and heart failure, malnutrition assessed by PNI is an independent predictor for all-cause death and cardiovascular death, and PNI is negatively correlated with the occurrence of adverse outcomes. |
format | Online Article Text |
id | pubmed-10443633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-104436332023-08-23 Prognostic Nutritional Index (PNI) as a Predictor in Patients with Metabolic Syndrome and Heart Failure Zhang, Xuehe Zhang, Jixin Liu, Fen Li, Wenling Zhang, Tong Fang, Binbin Zhang, Zhiyang Xie, Qian Yang, Yining Li, Xiaomei Diabetes Metab Syndr Obes Original Research PURPOSE: There is a lack of research on nutritional status and poor prognosis in patients with metabolic syndrome and heart failure. This study evaluated the relationship between nutritional status as defined by the PNI and adverse outcomes in patients with metabolic syndrome and heart failure. METHODS: A total of 1048 heart failure patients with metabolic syndrome admitted to the Heart Center of the First Affiliated Hospital of Xinjiang Medical University from January 2015 to December 2019 were consecutively. PNI was used to assess their nutritional status. RESULTS: A total of 51.0% of the patients were in the nonmalnutrition group (PNI≥45), 27.9% were in the mild malnutrition group (40≤PNI<45), and 21.1% of patients were in the malnutrition group (PNI<40). At 36 months of follow-up, after adjusting for other confounding factors, malnutrition (PNI<40) was independently associated with all-cause death (HR: 1.787, 95% CI: 1.451–2.201, P<0.001) and cardiovascular death (HR: 1.837, 95% CI: 1.467–2.301, P<0.001). PNI showed additional prognostic predictive value when included in the established risk factor model, both for all-cause death (AUC: 0.620, 95% CI: 0.579–0.661, P<0.001) and cardiovascular death (AUC: 0.596, 95% CI: 0.555–0.636, P<0.001). CONCLUSION: In patients with metabolic syndrome and heart failure, malnutrition assessed by PNI is an independent predictor for all-cause death and cardiovascular death, and PNI is negatively correlated with the occurrence of adverse outcomes. Dove 2023-08-18 /pmc/articles/PMC10443633/ /pubmed/37614379 http://dx.doi.org/10.2147/DMSO.S420924 Text en © 2023 Zhang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Zhang, Xuehe Zhang, Jixin Liu, Fen Li, Wenling Zhang, Tong Fang, Binbin Zhang, Zhiyang Xie, Qian Yang, Yining Li, Xiaomei Prognostic Nutritional Index (PNI) as a Predictor in Patients with Metabolic Syndrome and Heart Failure |
title | Prognostic Nutritional Index (PNI) as a Predictor in Patients with Metabolic Syndrome and Heart Failure |
title_full | Prognostic Nutritional Index (PNI) as a Predictor in Patients with Metabolic Syndrome and Heart Failure |
title_fullStr | Prognostic Nutritional Index (PNI) as a Predictor in Patients with Metabolic Syndrome and Heart Failure |
title_full_unstemmed | Prognostic Nutritional Index (PNI) as a Predictor in Patients with Metabolic Syndrome and Heart Failure |
title_short | Prognostic Nutritional Index (PNI) as a Predictor in Patients with Metabolic Syndrome and Heart Failure |
title_sort | prognostic nutritional index (pni) as a predictor in patients with metabolic syndrome and heart failure |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443633/ https://www.ncbi.nlm.nih.gov/pubmed/37614379 http://dx.doi.org/10.2147/DMSO.S420924 |
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