Cargando…
The value of RPS15 and MRPS27 in ischemic stroke
Ischemic stroke is caused by insufficient blood supply to the brain. It has acute onset, often disturbance of consciousness, and high mortality and disability rate. However, relationship between ribosomal proteins (RP)-S15 and mitochondrial ribosomal proteins (MRP)-S27 and ischemic stroke remains un...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443774/ https://www.ncbi.nlm.nih.gov/pubmed/37603533 http://dx.doi.org/10.1097/MD.0000000000034706 |
_version_ | 1785093909902262272 |
---|---|
author | Zhao, Man Liu, Aixian Mo, Linhong Wan, Guiling Lu, Fang |
author_facet | Zhao, Man Liu, Aixian Mo, Linhong Wan, Guiling Lu, Fang |
author_sort | Zhao, Man |
collection | PubMed |
description | Ischemic stroke is caused by insufficient blood supply to the brain. It has acute onset, often disturbance of consciousness, and high mortality and disability rate. However, relationship between ribosomal proteins (RP)-S15 and mitochondrial ribosomal proteins (MRP)-S27 and ischemic stroke remains unclear. The ischemic stroke datasets GSE22255, GSE16561, and GSE199435 were downloaded from gene expression omnibus generated by GPL6883, GPL11154, and GPL570. Differentially expressed genes (DEGs) were screened, and the construction and analysis of protein-protein interaction network, functional enrichment analysis and gene set enrichment analysis were performed. The gene expression heat map was drawn. Comparative toxicogenomics database analysis were performed to find the disease most related to core gene. TargetScan screened miRNAs that regulated central DEGs. Five hundred DEGs were identified. According to gene ontology analysis, they were mainly enriched in leukocyte activation, myoid cell activation involved in immune response, cell membrane, mitochondria, secretory vesicles, catalytic activity, enzyme binding, ribonucleic acid binding, splicing. Gene set enrichment analysis showed that the enrichment items are similar to the enrichment items of differentially expressed genes. And 20 core genes were obtained. Comparative toxicogenomics database analysis showed that 6 genes (RPS15, RPS2, RPS3, MRPS27, POLR2A, MRPS26) were found to be associated with chemical and drug-induced liver injury, necrosis, delayed prenatal exposure, nephropathy, hepatomegaly and tumor. RPS15 and MRPS27 are the core genes of ischemic stroke and play an important role in ischemic stroke. |
format | Online Article Text |
id | pubmed-10443774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-104437742023-08-23 The value of RPS15 and MRPS27 in ischemic stroke Zhao, Man Liu, Aixian Mo, Linhong Wan, Guiling Lu, Fang Medicine (Baltimore) 4100 Ischemic stroke is caused by insufficient blood supply to the brain. It has acute onset, often disturbance of consciousness, and high mortality and disability rate. However, relationship between ribosomal proteins (RP)-S15 and mitochondrial ribosomal proteins (MRP)-S27 and ischemic stroke remains unclear. The ischemic stroke datasets GSE22255, GSE16561, and GSE199435 were downloaded from gene expression omnibus generated by GPL6883, GPL11154, and GPL570. Differentially expressed genes (DEGs) were screened, and the construction and analysis of protein-protein interaction network, functional enrichment analysis and gene set enrichment analysis were performed. The gene expression heat map was drawn. Comparative toxicogenomics database analysis were performed to find the disease most related to core gene. TargetScan screened miRNAs that regulated central DEGs. Five hundred DEGs were identified. According to gene ontology analysis, they were mainly enriched in leukocyte activation, myoid cell activation involved in immune response, cell membrane, mitochondria, secretory vesicles, catalytic activity, enzyme binding, ribonucleic acid binding, splicing. Gene set enrichment analysis showed that the enrichment items are similar to the enrichment items of differentially expressed genes. And 20 core genes were obtained. Comparative toxicogenomics database analysis showed that 6 genes (RPS15, RPS2, RPS3, MRPS27, POLR2A, MRPS26) were found to be associated with chemical and drug-induced liver injury, necrosis, delayed prenatal exposure, nephropathy, hepatomegaly and tumor. RPS15 and MRPS27 are the core genes of ischemic stroke and play an important role in ischemic stroke. Lippincott Williams & Wilkins 2023-08-18 /pmc/articles/PMC10443774/ /pubmed/37603533 http://dx.doi.org/10.1097/MD.0000000000034706 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 4100 Zhao, Man Liu, Aixian Mo, Linhong Wan, Guiling Lu, Fang The value of RPS15 and MRPS27 in ischemic stroke |
title | The value of RPS15 and MRPS27 in ischemic stroke |
title_full | The value of RPS15 and MRPS27 in ischemic stroke |
title_fullStr | The value of RPS15 and MRPS27 in ischemic stroke |
title_full_unstemmed | The value of RPS15 and MRPS27 in ischemic stroke |
title_short | The value of RPS15 and MRPS27 in ischemic stroke |
title_sort | value of rps15 and mrps27 in ischemic stroke |
topic | 4100 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443774/ https://www.ncbi.nlm.nih.gov/pubmed/37603533 http://dx.doi.org/10.1097/MD.0000000000034706 |
work_keys_str_mv | AT zhaoman thevalueofrps15andmrps27inischemicstroke AT liuaixian thevalueofrps15andmrps27inischemicstroke AT molinhong thevalueofrps15andmrps27inischemicstroke AT wanguiling thevalueofrps15andmrps27inischemicstroke AT lufang thevalueofrps15andmrps27inischemicstroke AT zhaoman valueofrps15andmrps27inischemicstroke AT liuaixian valueofrps15andmrps27inischemicstroke AT molinhong valueofrps15andmrps27inischemicstroke AT wanguiling valueofrps15andmrps27inischemicstroke AT lufang valueofrps15andmrps27inischemicstroke |