Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation

We previously reported that measles virus nucleocapsid protein (MVNP) expression in osteoclasts (OCLs) of patients with Paget disease (PD) or targeted to the OCL lineage in MVNP-transgenic mice (MVNP mice) increases IGF1 production in osteoclasts (OCL-IGF1) and leads to development of PD OCLs and pa...

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Detalles Bibliográficos
Autores principales: Miyagawa, Kazuaki, Tenshin, Hirofumi, Mulcrone, Patrick L., Delgado-Calle, Jesus, Subler, Mark A., Windle, Jolene J., Chirgwin, John M., Roodman, G. David, Kurihara, Noriyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443794/
https://www.ncbi.nlm.nih.gov/pubmed/37338990
http://dx.doi.org/10.1172/jci.insight.159838

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