Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment

Chemotherapy-related cognitive impairment (CRCI) or “chemo brain” is a devastating neurotoxic sequela of cancer-related treatments, especially for the elderly individuals. Here we show that PTPRO, a tyrosine phosphatase, is highly enriched in the hippocampus, and its level is tightly associated with...

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Detalles Bibliográficos
Autores principales: Yao, Zhimeng, Dong, Hongmei, Zhu, Jianlin, Du, Liang, Luo, Yichen, Liu, Qing, Liu, Shixin, Lin, Yusheng, Wang, Lu, Wang, Shuhong, Wei, Wei, Zhang, Keke, Huang, Qingjun, Yu, Xiaojun, Zhao, Weijiang, Xu, Haiyun, Qiu, Xiaofu, Pan, Yunlong, Huang, Xingxu, Jim Yeung, Sai-Ching, Zhang, Dianzheng, Zhang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443805/
https://www.ncbi.nlm.nih.gov/pubmed/37485875
http://dx.doi.org/10.1172/jci.insight.166306

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