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P2Y(2) receptor decreases blood pressure by inhibiting ENaC

Stimulating the Gq-coupled P2Y(2) receptor (P2ry2) lowers blood pressure. Global knockout of P2ry2 increases blood pressure. Vascular and renal mechanisms are believed to participate in P2ry2 effects on blood pressure. To isolate the role of the kidneys in P2ry2 effects on blood pressure and to reve...

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Detalles Bibliográficos
Autores principales:	Soares, Antonio G., Contreras, Jorge, Mironova, Elena, Archer, Crystal R., Stockand, James D., Abd El-Aziz, Tarek Mohamed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443811/ https://www.ncbi.nlm.nih.gov/pubmed/37279066 http://dx.doi.org/10.1172/jci.insight.167704

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