Circulating cell-free methylated DNA reveals tissue-specific, cellular damage from radiation treatment

Radiation therapy is an effective cancer treatment, although damage to healthy tissues is common. Here we analyzed cell-free, methylated DNA released from dying cells into the circulation to evaluate radiation-induced cellular damage in different tissues. To map the circulating DNA fragments to huma...

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Detalles Bibliográficos
Autores principales: McNamara, Megan E., Loyfer, Netanel, Kiliti, Amber J., Schmidt, Marcel O., Shabi-Porat, Sapir, Jain, Sidharth S., Martinez Roth, Sarah, McDeed, A. Patrick, Shahrour, Nesreen, Ballew, Elizabeth, Lin, Yun-Tien, Li, Heng-Hong, Deslattes Mays, Anne, Rudra, Sonali, Riegel, Anna T., Unger, Keith, Kaplan, Tommy, Wellstein, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443812/
https://www.ncbi.nlm.nih.gov/pubmed/37318863
http://dx.doi.org/10.1172/jci.insight.156529

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