Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potential new treatment route for amyotrophic lateral sclerosis

Riluzole is the only treatment known to improve survival in patients with Amyotrophic Lateral Sclerosis (ALS). However, oral riluzole efficacy is modest at best, further it is known to have large inter-individual variability of serum concentration and clearance, is formulated as an oral drug in a pa...

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Detalles Bibliográficos
Autores principales: Keifer, Orion P., Gutierrez, Juanmarco, Butt, Mark T., Cramer, Sarah D., Bartus, Raymond, Tansey, Malu, Deaver, Daniel, Betourne, Alexandre, Boulis, Nicholas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443869/
https://www.ncbi.nlm.nih.gov/pubmed/37607205
http://dx.doi.org/10.1371/journal.pone.0277718

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