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Stauffer Syndrome: Another Strange Case of the Internist's Tumor

Stauffer syndrome is a paraneoplastic disorder associated with renal cell carcinoma (RCC), which often can be the first manifestation of the tumor. It is characterized by nephrogenic hepatic dysfunction that reverses after removing the primary tumor. Stauffer syndrome has been associated with a wors...

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Autores principales: Muñoz Rossi, Felipe A, Gallo, Diana, Guaiquil, Ana Maria, Suarez, Ralf, Ricardo Ossio, Gina Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443892/
https://www.ncbi.nlm.nih.gov/pubmed/37614277
http://dx.doi.org/10.7759/cureus.42307
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author Muñoz Rossi, Felipe A
Gallo, Diana
Guaiquil, Ana Maria
Suarez, Ralf
Ricardo Ossio, Gina Paola
author_facet Muñoz Rossi, Felipe A
Gallo, Diana
Guaiquil, Ana Maria
Suarez, Ralf
Ricardo Ossio, Gina Paola
author_sort Muñoz Rossi, Felipe A
collection PubMed
description Stauffer syndrome is a paraneoplastic disorder associated with renal cell carcinoma (RCC), which often can be the first manifestation of the tumor. It is characterized by nephrogenic hepatic dysfunction that reverses after removing the primary tumor. Stauffer syndrome has been associated with a worse prognosis in patients with RCC. We are presenting a case of a patient with an uncommon cholestatic jaundice variant. The patient also had hepatic profile alterations, but no metastasis existed. These findings meet the diagnostic criteria for Stauffer syndrome in the context of RCC as the first clinical manifestation in the diagnostic approach to malignancy-associated disease. A 74-year-old patient, with a history of obesity, hypertension, and type 2 diabetes mellitus, went for advice due to right upper abdominal pain, icterus accompanied by emetic episodes, and a cholestatic pattern in the hepatic profile. Autoimmune hepatitis was ruled out based on immunological testing. Imaging revealed evidence of a mass in the lower pole of the right kidney, suspicious of malignant neoplasia, and a distant paraneoplastic syndrome consistent with the cholestatic variant of Stauffer syndrome. This is an exciting case of Stauffer syndrome as the initial presentation of RCC associated with a cholestatic variant, providing relevant information about this uncommon condition in our setting.
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spelling pubmed-104438922023-08-23 Stauffer Syndrome: Another Strange Case of the Internist's Tumor Muñoz Rossi, Felipe A Gallo, Diana Guaiquil, Ana Maria Suarez, Ralf Ricardo Ossio, Gina Paola Cureus Internal Medicine Stauffer syndrome is a paraneoplastic disorder associated with renal cell carcinoma (RCC), which often can be the first manifestation of the tumor. It is characterized by nephrogenic hepatic dysfunction that reverses after removing the primary tumor. Stauffer syndrome has been associated with a worse prognosis in patients with RCC. We are presenting a case of a patient with an uncommon cholestatic jaundice variant. The patient also had hepatic profile alterations, but no metastasis existed. These findings meet the diagnostic criteria for Stauffer syndrome in the context of RCC as the first clinical manifestation in the diagnostic approach to malignancy-associated disease. A 74-year-old patient, with a history of obesity, hypertension, and type 2 diabetes mellitus, went for advice due to right upper abdominal pain, icterus accompanied by emetic episodes, and a cholestatic pattern in the hepatic profile. Autoimmune hepatitis was ruled out based on immunological testing. Imaging revealed evidence of a mass in the lower pole of the right kidney, suspicious of malignant neoplasia, and a distant paraneoplastic syndrome consistent with the cholestatic variant of Stauffer syndrome. This is an exciting case of Stauffer syndrome as the initial presentation of RCC associated with a cholestatic variant, providing relevant information about this uncommon condition in our setting. Cureus 2023-07-22 /pmc/articles/PMC10443892/ /pubmed/37614277 http://dx.doi.org/10.7759/cureus.42307 Text en Copyright © 2023, Muñoz Rossi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Muñoz Rossi, Felipe A
Gallo, Diana
Guaiquil, Ana Maria
Suarez, Ralf
Ricardo Ossio, Gina Paola
Stauffer Syndrome: Another Strange Case of the Internist's Tumor
title Stauffer Syndrome: Another Strange Case of the Internist's Tumor
title_full Stauffer Syndrome: Another Strange Case of the Internist's Tumor
title_fullStr Stauffer Syndrome: Another Strange Case of the Internist's Tumor
title_full_unstemmed Stauffer Syndrome: Another Strange Case of the Internist's Tumor
title_short Stauffer Syndrome: Another Strange Case of the Internist's Tumor
title_sort stauffer syndrome: another strange case of the internist's tumor
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443892/
https://www.ncbi.nlm.nih.gov/pubmed/37614277
http://dx.doi.org/10.7759/cureus.42307
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