Selection of bispecific antibodies with optimal developability using FcRn‑Ph‑HPLC as an optimized FcRn affinity chromatography method

A challenge when developing therapeutic antibodies is the identification of candidates with favorable pharmacokinetics (PK) early in development. A key determinant of immunoglobulin (IgG) serum half‑life in vivo is the efficiency of pH-dependent binding to the neonatal Fc receptor (FcRn). Numerous s...

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Detalles Bibliográficos
Autores principales: Müller, Thomas, Tasser, Carolin, Tesar, Michael, Fucek, Ivica, Schniegler-Mattox, Ute, Koch, Joachim, Ellwanger, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443974/
https://www.ncbi.nlm.nih.gov/pubmed/37599441
http://dx.doi.org/10.1080/19420862.2023.2245519

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