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Case Report: Long-term remission of malignant pleural and peritoneal effusion in a case of advanced lung adenocarcinoma treated with combined crizotinib and anlotinib therapy

Malignant pleural and peritoneal effusion are common clinical manifestations in advanced malignant tumors, associated with a poor prognosis. This article presents a case of advanced lung adenocarcinoma with ROS1 rearrangement, characterized by persistent malignant pleural and peritoneal effusion. Th...

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Autores principales: Tian, Jin, Long, Lin, Zang, Jianhua, Liu, Peng, Zhao, Lili, Zhang, Hongtao, Xiao, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444195/
https://www.ncbi.nlm.nih.gov/pubmed/37614510
http://dx.doi.org/10.3389/fonc.2023.1191522
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author Tian, Jin
Long, Lin
Zang, Jianhua
Liu, Peng
Zhao, Lili
Zhang, Hongtao
Xiao, Jun
author_facet Tian, Jin
Long, Lin
Zang, Jianhua
Liu, Peng
Zhao, Lili
Zhang, Hongtao
Xiao, Jun
author_sort Tian, Jin
collection PubMed
description Malignant pleural and peritoneal effusion are common clinical manifestations in advanced malignant tumors, associated with a poor prognosis. This article presents a case of advanced lung adenocarcinoma with ROS1 rearrangement, characterized by persistent malignant pleural and peritoneal effusion. The patient received combined therapy of Crizotinib and Anlotinib, resulting in a significant reduction and even disappearance of the malignant effusion. Exploratory use of this treatment approach improved the patient’s quality of life and holds potential for extending overall survival. However, given the single case report nature, the efficacy of this regimen in treating advanced ROS1-rearranged lung adenocarcinoma should be considered as a supplementary strategy, warranting further validation through multicenter clinical data.
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spelling pubmed-104441952023-08-23 Case Report: Long-term remission of malignant pleural and peritoneal effusion in a case of advanced lung adenocarcinoma treated with combined crizotinib and anlotinib therapy Tian, Jin Long, Lin Zang, Jianhua Liu, Peng Zhao, Lili Zhang, Hongtao Xiao, Jun Front Oncol Oncology Malignant pleural and peritoneal effusion are common clinical manifestations in advanced malignant tumors, associated with a poor prognosis. This article presents a case of advanced lung adenocarcinoma with ROS1 rearrangement, characterized by persistent malignant pleural and peritoneal effusion. The patient received combined therapy of Crizotinib and Anlotinib, resulting in a significant reduction and even disappearance of the malignant effusion. Exploratory use of this treatment approach improved the patient’s quality of life and holds potential for extending overall survival. However, given the single case report nature, the efficacy of this regimen in treating advanced ROS1-rearranged lung adenocarcinoma should be considered as a supplementary strategy, warranting further validation through multicenter clinical data. Frontiers Media S.A. 2023-08-08 /pmc/articles/PMC10444195/ /pubmed/37614510 http://dx.doi.org/10.3389/fonc.2023.1191522 Text en Copyright © 2023 Tian, Long, Zang, Liu, Zhao, Zhang and Xiao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Tian, Jin
Long, Lin
Zang, Jianhua
Liu, Peng
Zhao, Lili
Zhang, Hongtao
Xiao, Jun
Case Report: Long-term remission of malignant pleural and peritoneal effusion in a case of advanced lung adenocarcinoma treated with combined crizotinib and anlotinib therapy
title Case Report: Long-term remission of malignant pleural and peritoneal effusion in a case of advanced lung adenocarcinoma treated with combined crizotinib and anlotinib therapy
title_full Case Report: Long-term remission of malignant pleural and peritoneal effusion in a case of advanced lung adenocarcinoma treated with combined crizotinib and anlotinib therapy
title_fullStr Case Report: Long-term remission of malignant pleural and peritoneal effusion in a case of advanced lung adenocarcinoma treated with combined crizotinib and anlotinib therapy
title_full_unstemmed Case Report: Long-term remission of malignant pleural and peritoneal effusion in a case of advanced lung adenocarcinoma treated with combined crizotinib and anlotinib therapy
title_short Case Report: Long-term remission of malignant pleural and peritoneal effusion in a case of advanced lung adenocarcinoma treated with combined crizotinib and anlotinib therapy
title_sort case report: long-term remission of malignant pleural and peritoneal effusion in a case of advanced lung adenocarcinoma treated with combined crizotinib and anlotinib therapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444195/
https://www.ncbi.nlm.nih.gov/pubmed/37614510
http://dx.doi.org/10.3389/fonc.2023.1191522
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