Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration

Human induced pluripotent stem cells (iPSCs) are a renewable cell source that can be differentiated into neural progenitor cells (iNPCs) and transduced with glial cell line-derived neurotrophic factor (iNPC-GDNFs). The goal of the current study is to characterize iNPC-GDNFs and test their therapeuti...

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Detalles Bibliográficos
Autores principales: Laperle, Alexander H., Moser, V. Alexandra, Avalos, Pablo, Lu, Bin, Wu, Amanda, Fulton, Aaron, Ramirez, Stephany, Garcia, Veronica J., Bell, Shaughn, Ho, Ritchie, Lawless, George, Roxas, Kristina, Shahin, Saba, Shelest, Oksana, Svendsen, Soshana, Wang, Shaomei, Svendsen, Clive N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444557/
https://www.ncbi.nlm.nih.gov/pubmed/37084724
http://dx.doi.org/10.1016/j.stemcr.2023.03.016

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