An in silico and in vitro human neuronal network model reveals cellular mechanisms beyond Na(V)1.1 underlying Dravet syndrome

Human induced pluripotent stem cell (hiPSC)-derived neuronal networks on multi-electrode arrays (MEAs) provide a unique phenotyping tool to study neurological disorders. However, it is difficult to infer cellular mechanisms underlying these phenotypes. Computational modeling can utilize the rich dat...

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Detalles Bibliográficos
Autores principales: Doorn, Nina, van Hugte, Eline J.H., Ciptasari, Ummi, Mordelt, Annika, Meijer, Hil G.E., Schubert, Dirk, Frega, Monica, Nadif Kasri, Nael, van Putten, Michel J.A.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444571/
https://www.ncbi.nlm.nih.gov/pubmed/37419110
http://dx.doi.org/10.1016/j.stemcr.2023.06.003

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