Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors

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The desmoplastic stroma in solid tumors presents a formidable challenge to immunotherapies that rely on endogenous or adoptively transferred T cells, however, the mechanisms are poorly understood. To define mechanisms involved, here we treat established desmoplastic pancreatic tumors with CAR T cell...

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Detalles Bibliográficos
Autores principales: Xiao, Zebin, Todd, Leslie, Huang, Li, Noguera-Ortega, Estela, Lu, Zhen, Huang, Lili, Kopp, Meghan, Li, Yue, Pattada, Nimisha, Zhong, Wenqun, Guo, Wei, Scholler, John, Liousia, Maria, Assenmacher, Charles-Antoine, June, Carl H., Albelda, Steven M., Puré, Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444764/
https://www.ncbi.nlm.nih.gov/pubmed/37607999
http://dx.doi.org/10.1038/s41467-023-40850-5
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