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Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides
Antimicrobial peptides (AMPs) are important mediators of intestinal immune surveillance. However, the regional heterogeneity of AMPs and its regulatory mechanisms remain obscure. Here, we clarified the regional heterogeneity of intestinal AMPs at the single-cell level, and revealed a cross-lineages...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444805/ https://www.ncbi.nlm.nih.gov/pubmed/37607912 http://dx.doi.org/10.1038/s41467-023-40565-7 |
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| author | Wang, Yue Yu, Yanbo Li, Lixiang Zheng, Mengqi Zhou, Jiawei Gong, Haifan Feng, Bingcheng Wang, Xiao Meng, Xuanlin Cui, Yanyan Xia, Yanan Chu, Shuzheng Lin, Lin Chang, Huijun Zhou, Ruchen Ma, Mingjun Li, Zhen Ji, Rui Lu, Ming Yang, Xiaoyun Zuo, Xiuli Li, Shiyang Li, Yanqing |
| author_facet | Wang, Yue Yu, Yanbo Li, Lixiang Zheng, Mengqi Zhou, Jiawei Gong, Haifan Feng, Bingcheng Wang, Xiao Meng, Xuanlin Cui, Yanyan Xia, Yanan Chu, Shuzheng Lin, Lin Chang, Huijun Zhou, Ruchen Ma, Mingjun Li, Zhen Ji, Rui Lu, Ming Yang, Xiaoyun Zuo, Xiuli Li, Shiyang Li, Yanqing |
| author_sort | Wang, Yue |
| collection | PubMed |
| description | Antimicrobial peptides (AMPs) are important mediators of intestinal immune surveillance. However, the regional heterogeneity of AMPs and its regulatory mechanisms remain obscure. Here, we clarified the regional heterogeneity of intestinal AMPs at the single-cell level, and revealed a cross-lineages AMP regulation mechanism that bile acid dependent transcription factors (BATFs), NR1H4, NR1H3 and VDR, regulate AMPs through a ligand-independent manner. Bile acids regulate AMPs by perturbing cell differentiation rather than activating BATFs signaling. Chromatin accessibility determines the potential of BATFs to regulate AMPs at the pre-transcriptional level, thus shaping the regional heterogeneity of AMPs. The BATFs-AMPs axis also participates in the establishment of intestinal antimicrobial barriers of fetuses and the defects of antibacterial ability during Crohn’s disease. Overall, BATFs and chromatin accessibility play essential roles in shaping the regional heterogeneity of AMPs at pre- and postnatal stages, as well as in maintenance of antimicrobial immunity during homeostasis and disease. |
| format | Online Article Text |
| id | pubmed-10444805 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-104448052023-08-24 Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides Wang, Yue Yu, Yanbo Li, Lixiang Zheng, Mengqi Zhou, Jiawei Gong, Haifan Feng, Bingcheng Wang, Xiao Meng, Xuanlin Cui, Yanyan Xia, Yanan Chu, Shuzheng Lin, Lin Chang, Huijun Zhou, Ruchen Ma, Mingjun Li, Zhen Ji, Rui Lu, Ming Yang, Xiaoyun Zuo, Xiuli Li, Shiyang Li, Yanqing Nat Commun Article Antimicrobial peptides (AMPs) are important mediators of intestinal immune surveillance. However, the regional heterogeneity of AMPs and its regulatory mechanisms remain obscure. Here, we clarified the regional heterogeneity of intestinal AMPs at the single-cell level, and revealed a cross-lineages AMP regulation mechanism that bile acid dependent transcription factors (BATFs), NR1H4, NR1H3 and VDR, regulate AMPs through a ligand-independent manner. Bile acids regulate AMPs by perturbing cell differentiation rather than activating BATFs signaling. Chromatin accessibility determines the potential of BATFs to regulate AMPs at the pre-transcriptional level, thus shaping the regional heterogeneity of AMPs. The BATFs-AMPs axis also participates in the establishment of intestinal antimicrobial barriers of fetuses and the defects of antibacterial ability during Crohn’s disease. Overall, BATFs and chromatin accessibility play essential roles in shaping the regional heterogeneity of AMPs at pre- and postnatal stages, as well as in maintenance of antimicrobial immunity during homeostasis and disease. Nature Publishing Group UK 2023-08-22 /pmc/articles/PMC10444805/ /pubmed/37607912 http://dx.doi.org/10.1038/s41467-023-40565-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Wang, Yue Yu, Yanbo Li, Lixiang Zheng, Mengqi Zhou, Jiawei Gong, Haifan Feng, Bingcheng Wang, Xiao Meng, Xuanlin Cui, Yanyan Xia, Yanan Chu, Shuzheng Lin, Lin Chang, Huijun Zhou, Ruchen Ma, Mingjun Li, Zhen Ji, Rui Lu, Ming Yang, Xiaoyun Zuo, Xiuli Li, Shiyang Li, Yanqing Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides |
| title | Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides |
| title_full | Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides |
| title_fullStr | Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides |
| title_full_unstemmed | Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides |
| title_short | Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides |
| title_sort | bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444805/ https://www.ncbi.nlm.nih.gov/pubmed/37607912 http://dx.doi.org/10.1038/s41467-023-40565-7 |
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