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Rapid progression of heart failure secondary to radioactive iodine treatment of hyperthyroidism: A case report

BACKGROUND: The deterioration of thyroid health is involved in the progression of heart failure (HF). This is usually a lengthy process, so there are almost no reports on its rapid development. Here we report a case of a young male who rapidly developed hypothyroid cardiomyopathy secondary to radioa...

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Autores principales: Li, Zi-Han, Ni, Lu-Jia, Liu, Yuan-Qiao, Si, Dao-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445058/
https://www.ncbi.nlm.nih.gov/pubmed/37621594
http://dx.doi.org/10.12998/wjcc.v11.i22.5316
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author Li, Zi-Han
Ni, Lu-Jia
Liu, Yuan-Qiao
Si, Dao-Yuan
author_facet Li, Zi-Han
Ni, Lu-Jia
Liu, Yuan-Qiao
Si, Dao-Yuan
author_sort Li, Zi-Han
collection PubMed
description BACKGROUND: The deterioration of thyroid health is involved in the progression of heart failure (HF). This is usually a lengthy process, so there are almost no reports on its rapid development. Here we report a case of a young male who rapidly developed hypothyroid cardiomyopathy secondary to radioactive iodine treatment, suggesting that severe HF might occur even after a short period of hypothyroidism. CASE SUMMARY: A 26-year-old man was referred to our hospital for HF presenting with dyspnea on exertion and chest discomfort lasting for 1 mo. He received radioactive iodine treatment for hyperthyroidism 1 year ago and had an almost normal echocardiogram 6 mo ago. Admission echocardiogram and cardiac magnetic resonance (CMR) revealed left ventricle (LV) global hypokinesia and severely depressed systolic function. In addition, late gadolinium enhancement indicated no obvious changes in the myocardium. Thyroid function tests showed decreased serum levels of thyroid hormone (TH) and elevated thyroid-stimulating hormone. Based on an exclusionary examination, the patient was diagnosed with hypothyroid cardiomyopathy and was started on replacement therapy. His HF symptoms were completely relieved during the six-month follow-up, and echocardiogram and CMR revealed recovered LV size and ejection fraction. CONCLUSION: This report demonstrates that severe fluctuations in TH levels may lead to acute HF, which can completely recover with timely thyroid hormone replacement. In addition, our findings highlight the importance of routinely detecting cardiac function in patients treated with radioactive iodine.
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spelling pubmed-104450582023-08-24 Rapid progression of heart failure secondary to radioactive iodine treatment of hyperthyroidism: A case report Li, Zi-Han Ni, Lu-Jia Liu, Yuan-Qiao Si, Dao-Yuan World J Clin Cases Case Report BACKGROUND: The deterioration of thyroid health is involved in the progression of heart failure (HF). This is usually a lengthy process, so there are almost no reports on its rapid development. Here we report a case of a young male who rapidly developed hypothyroid cardiomyopathy secondary to radioactive iodine treatment, suggesting that severe HF might occur even after a short period of hypothyroidism. CASE SUMMARY: A 26-year-old man was referred to our hospital for HF presenting with dyspnea on exertion and chest discomfort lasting for 1 mo. He received radioactive iodine treatment for hyperthyroidism 1 year ago and had an almost normal echocardiogram 6 mo ago. Admission echocardiogram and cardiac magnetic resonance (CMR) revealed left ventricle (LV) global hypokinesia and severely depressed systolic function. In addition, late gadolinium enhancement indicated no obvious changes in the myocardium. Thyroid function tests showed decreased serum levels of thyroid hormone (TH) and elevated thyroid-stimulating hormone. Based on an exclusionary examination, the patient was diagnosed with hypothyroid cardiomyopathy and was started on replacement therapy. His HF symptoms were completely relieved during the six-month follow-up, and echocardiogram and CMR revealed recovered LV size and ejection fraction. CONCLUSION: This report demonstrates that severe fluctuations in TH levels may lead to acute HF, which can completely recover with timely thyroid hormone replacement. In addition, our findings highlight the importance of routinely detecting cardiac function in patients treated with radioactive iodine. Baishideng Publishing Group Inc 2023-08-06 2023-08-06 /pmc/articles/PMC10445058/ /pubmed/37621594 http://dx.doi.org/10.12998/wjcc.v11.i22.5316 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Li, Zi-Han
Ni, Lu-Jia
Liu, Yuan-Qiao
Si, Dao-Yuan
Rapid progression of heart failure secondary to radioactive iodine treatment of hyperthyroidism: A case report
title Rapid progression of heart failure secondary to radioactive iodine treatment of hyperthyroidism: A case report
title_full Rapid progression of heart failure secondary to radioactive iodine treatment of hyperthyroidism: A case report
title_fullStr Rapid progression of heart failure secondary to radioactive iodine treatment of hyperthyroidism: A case report
title_full_unstemmed Rapid progression of heart failure secondary to radioactive iodine treatment of hyperthyroidism: A case report
title_short Rapid progression of heart failure secondary to radioactive iodine treatment of hyperthyroidism: A case report
title_sort rapid progression of heart failure secondary to radioactive iodine treatment of hyperthyroidism: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445058/
https://www.ncbi.nlm.nih.gov/pubmed/37621594
http://dx.doi.org/10.12998/wjcc.v11.i22.5316
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