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Emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders

Extracellular vesicles (EVs) serve as cell-to-cell and inter-organ communicators by conveying proteins and nucleic acids with regulatory functions. Emerging evidence shows that gut microbial-released EVs play a pivotal role in the gut-brain axis, bidirectional communication, and crosstalk between th...

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Autores principales: Sun, Bowen, Sawant, Harshal, Borthakur, Alip, Bihl, Ji Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445154/
https://www.ncbi.nlm.nih.gov/pubmed/37621715
http://dx.doi.org/10.3389/fnins.2023.1241418
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author Sun, Bowen
Sawant, Harshal
Borthakur, Alip
Bihl, Ji Chen
author_facet Sun, Bowen
Sawant, Harshal
Borthakur, Alip
Bihl, Ji Chen
author_sort Sun, Bowen
collection PubMed
description Extracellular vesicles (EVs) serve as cell-to-cell and inter-organ communicators by conveying proteins and nucleic acids with regulatory functions. Emerging evidence shows that gut microbial-released EVs play a pivotal role in the gut-brain axis, bidirectional communication, and crosstalk between the gut and the brain. Increasing pre-clinical and clinical evidence suggests that gut bacteria-released EVs are capable of eliciting distinct signaling to the brain with the ability to cross the blood–brain barrier, exerting regulatory function on brain cells such as neurons, astrocytes, and microglia, via their abundant and diversified protein and nucleic acid cargo. Conversely, EVs derived from certain species of bacteria, particularly from gut commensals with probiotic properties, have recently been shown to confer distinct therapeutic effects on various neurological disorders. Thus, gut bacterial EVs may be both a cause of and therapy for neuropathological complications. This review marshals the basic, clinical, and translational studies that significantly contributed to our up-to-date knowledge of the therapeutic potential of gut microbial-derived EVs in treating neurological disorders, including strokes, Alzheimer’s and Parkinson’s disease, and dementia. The review also discusses the newer insights in recent studies focused on developing superior therapeutic microbial EVs via genetic manipulation and/or dietary intervention.
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spelling pubmed-104451542023-08-24 Emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders Sun, Bowen Sawant, Harshal Borthakur, Alip Bihl, Ji Chen Front Neurosci Neuroscience Extracellular vesicles (EVs) serve as cell-to-cell and inter-organ communicators by conveying proteins and nucleic acids with regulatory functions. Emerging evidence shows that gut microbial-released EVs play a pivotal role in the gut-brain axis, bidirectional communication, and crosstalk between the gut and the brain. Increasing pre-clinical and clinical evidence suggests that gut bacteria-released EVs are capable of eliciting distinct signaling to the brain with the ability to cross the blood–brain barrier, exerting regulatory function on brain cells such as neurons, astrocytes, and microglia, via their abundant and diversified protein and nucleic acid cargo. Conversely, EVs derived from certain species of bacteria, particularly from gut commensals with probiotic properties, have recently been shown to confer distinct therapeutic effects on various neurological disorders. Thus, gut bacterial EVs may be both a cause of and therapy for neuropathological complications. This review marshals the basic, clinical, and translational studies that significantly contributed to our up-to-date knowledge of the therapeutic potential of gut microbial-derived EVs in treating neurological disorders, including strokes, Alzheimer’s and Parkinson’s disease, and dementia. The review also discusses the newer insights in recent studies focused on developing superior therapeutic microbial EVs via genetic manipulation and/or dietary intervention. Frontiers Media S.A. 2023-08-09 /pmc/articles/PMC10445154/ /pubmed/37621715 http://dx.doi.org/10.3389/fnins.2023.1241418 Text en Copyright © 2023 Sun, Sawant, Borthakur and Bihl. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sun, Bowen
Sawant, Harshal
Borthakur, Alip
Bihl, Ji Chen
Emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders
title Emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders
title_full Emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders
title_fullStr Emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders
title_full_unstemmed Emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders
title_short Emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders
title_sort emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445154/
https://www.ncbi.nlm.nih.gov/pubmed/37621715
http://dx.doi.org/10.3389/fnins.2023.1241418
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