Impact of the angiotensin receptor‐neprilysin inhibitor in clinical diabetes management: Potential benefits and pitfalls

The possible mechanism of increased urinary C‐peptide due to neprilysin inhibitors is investigated. Neprilysin inhibition blocks degradation of natriuretic peptides, and elicits a natriuretic and antihypertensive effect. Neprilysin inhibition might similarly block degradation of C‐peptides in the ki...

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Detalles Bibliográficos
Autores principales: Kato, Tomoko, Murakami, Takaaki, Yabe, Daisuke, Harada, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445196/
https://www.ncbi.nlm.nih.gov/pubmed/37357546
http://dx.doi.org/10.1111/jdi.14044
Descripción
Sumario:The possible mechanism of increased urinary C‐peptide due to neprilysin inhibitors is investigated. Neprilysin inhibition blocks degradation of natriuretic peptides, and elicits a natriuretic and antihypertensive effect. Neprilysin inhibition might similarly block degradation of C‐peptides in the kidney and thus increase the urinary C‐peptide level.[Image: see text]

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