Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC–MS-Based Metabolomic Approaches

[Image: see text] Pexidartinib (PEX, TURALIO), a selective and potent inhibitor of the macrophage colony-stimulating factor-1 receptor, has been approved for the treatment of tenosynovial giant cell tumor. However, frequent and severe adverse effects have been reported in the clinic, resulting in a...

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Detalles Bibliográficos
Autores principales: Qin, Xuan, Wang, Yong, MacKenzie, Kevin R., Hakenjos, John M., Chen, Si, Khalil, Saleh M., Jung, Sung Yun, Young, Damian W., Guo, Lei, Li, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445284/
https://www.ncbi.nlm.nih.gov/pubmed/37531179
http://dx.doi.org/10.1021/acs.chemrestox.3c00164

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