Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings

AIMS: Human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have become an essential tool to study arrhythmia mechanisms. Much of the foundational work on these cells, as well as the computational models built from the resultant data, has overlooked the contribution of seal–leak curr...

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Detalles Bibliográficos
Autores principales: Clark, Alexander P, Clerx, Michael, Wei, Siyu, Lei, Chon Lok, de Boer, Teun P, Mirams, Gary R, Christini, David J, Krogh-Madsen, Trine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445319/
https://www.ncbi.nlm.nih.gov/pubmed/37552789
http://dx.doi.org/10.1093/europace/euad243

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