TP53 gain-of-function mutation modulates the immunosuppressive microenvironment in non-HPV-associated oral squamous cell carcinoma

BACKGROUND: TP53, the most mutated gene in solid cancers, has a profound impact on most hallmarks of cancer. Somatic TP53 mutations occur in high frequencies in head and neck cancers, including oral squamous cell carcinoma (OSCC). Our study aims to understand the role of TP53 gain-of-function mutati...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Yewen, Ren, Xiaoyong, Cao, Shaolong, Chen, Xi, Yuan, Bo, Brasil da Costa, Fabio Henrique, Rodriguez Rosario, Alanis E, Corona, Arnoldo, Michikawa, Chieko, Veeramachaneni, Ratna, Osman, Abdullah A, Xie, Tongxin, Wang, Wenyi, Sikora, Andrew G, Myers, Jeffrey N, Rangel, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445354/
https://www.ncbi.nlm.nih.gov/pubmed/37604640
http://dx.doi.org/10.1136/jitc-2023-006666

Ejemplares similares

Ejemplares similares