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Association between smoking and colorectal cancer in Eastern Mediterranean Regional Office (EMRO): A systematic review and meta-analysis
BACKGROUND: Smoking poses a significant risk for colorectal cancer (CRC), considered the third leading reason for cancer-related deaths worldwide. However, there has been limited research on the relationship between smoking and CRC in the Eastern Mediterranean Regional Office (EMRO). Therefore, a me...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445494/ https://www.ncbi.nlm.nih.gov/pubmed/37470665 http://dx.doi.org/10.4103/sjg.sjg_163_23 |
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author | Keivanlou, Mohammad-Hossein Amini-Salehi, Ehsan Hassanipour, Soheil Mahapatro, Abinash Raghuma, Nakka Joukar, Farahnaz Letafatkar, Negin Habibi, Arman Norouzi, Naeim Aleali, Maryam Sadat Javid, Mona Mirdamadi, Arian Mansour-Ghanaei, Fariborz |
author_facet | Keivanlou, Mohammad-Hossein Amini-Salehi, Ehsan Hassanipour, Soheil Mahapatro, Abinash Raghuma, Nakka Joukar, Farahnaz Letafatkar, Negin Habibi, Arman Norouzi, Naeim Aleali, Maryam Sadat Javid, Mona Mirdamadi, Arian Mansour-Ghanaei, Fariborz |
author_sort | Keivanlou, Mohammad-Hossein |
collection | PubMed |
description | BACKGROUND: Smoking poses a significant risk for colorectal cancer (CRC), considered the third leading reason for cancer-related deaths worldwide. However, there has been limited research on the relationship between smoking and CRC in the Eastern Mediterranean Regional Office (EMRO). Therefore, a meta-analysis was conducted to combine available data and gain a comprehensive understanding of the relationship between smoking and CRC in EMRO. METHODS: Two independent researchers searched PubMed, Scopus, and Web of Science until December 2022. The included studies were checked for risk of bias administering the Newcastle-Ottawa scale. Heterogeneity was evaluated using I2 statistics and the Cochrane test. Publication bias was determined through funnel plot analysis and Egger’s regression test. Additionally, a meta-regression analysis explored the impact of a country’s Human Development Index (HDI) on the relationship between smoking and CRC. RESULTS: The final analysis included 26 studies, revealing a significant association between smoking and CRC (OR = 1.40; 95% CI: 1.11 - 1.78; P = 0.004). Moreover, smoking had a more pronounced adverse effect on CRC in countries with higher HDIs compared to those with lower HDIs (OR = 1.30; 95% CI: 0.99 - 1.71; P = 0.054). CONCLUSIONS: Our findings underscore the importance of implementing smoking cessation programs and policies in EMRO countries, as they demonstrate a positive relationship between smoking and the risk of CRC. Furthermore, the results suggest that a country’s level of human development may influence the association between smoking and CRC. Further research is needed to investigate this potential connection and develop targeted public health interventions. |
format | Online Article Text |
id | pubmed-10445494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-104454942023-08-24 Association between smoking and colorectal cancer in Eastern Mediterranean Regional Office (EMRO): A systematic review and meta-analysis Keivanlou, Mohammad-Hossein Amini-Salehi, Ehsan Hassanipour, Soheil Mahapatro, Abinash Raghuma, Nakka Joukar, Farahnaz Letafatkar, Negin Habibi, Arman Norouzi, Naeim Aleali, Maryam Sadat Javid, Mona Mirdamadi, Arian Mansour-Ghanaei, Fariborz Saudi J Gastroenterol Systematic Review/Meta-Analysis BACKGROUND: Smoking poses a significant risk for colorectal cancer (CRC), considered the third leading reason for cancer-related deaths worldwide. However, there has been limited research on the relationship between smoking and CRC in the Eastern Mediterranean Regional Office (EMRO). Therefore, a meta-analysis was conducted to combine available data and gain a comprehensive understanding of the relationship between smoking and CRC in EMRO. METHODS: Two independent researchers searched PubMed, Scopus, and Web of Science until December 2022. The included studies were checked for risk of bias administering the Newcastle-Ottawa scale. Heterogeneity was evaluated using I2 statistics and the Cochrane test. Publication bias was determined through funnel plot analysis and Egger’s regression test. Additionally, a meta-regression analysis explored the impact of a country’s Human Development Index (HDI) on the relationship between smoking and CRC. RESULTS: The final analysis included 26 studies, revealing a significant association between smoking and CRC (OR = 1.40; 95% CI: 1.11 - 1.78; P = 0.004). Moreover, smoking had a more pronounced adverse effect on CRC in countries with higher HDIs compared to those with lower HDIs (OR = 1.30; 95% CI: 0.99 - 1.71; P = 0.054). CONCLUSIONS: Our findings underscore the importance of implementing smoking cessation programs and policies in EMRO countries, as they demonstrate a positive relationship between smoking and the risk of CRC. Furthermore, the results suggest that a country’s level of human development may influence the association between smoking and CRC. Further research is needed to investigate this potential connection and develop targeted public health interventions. Wolters Kluwer - Medknow 2023-07-04 /pmc/articles/PMC10445494/ /pubmed/37470665 http://dx.doi.org/10.4103/sjg.sjg_163_23 Text en Copyright: © 2023 Saudi Journal of Gastroenterology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Systematic Review/Meta-Analysis Keivanlou, Mohammad-Hossein Amini-Salehi, Ehsan Hassanipour, Soheil Mahapatro, Abinash Raghuma, Nakka Joukar, Farahnaz Letafatkar, Negin Habibi, Arman Norouzi, Naeim Aleali, Maryam Sadat Javid, Mona Mirdamadi, Arian Mansour-Ghanaei, Fariborz Association between smoking and colorectal cancer in Eastern Mediterranean Regional Office (EMRO): A systematic review and meta-analysis |
title | Association between smoking and colorectal cancer in Eastern Mediterranean Regional Office (EMRO): A systematic review and meta-analysis |
title_full | Association between smoking and colorectal cancer in Eastern Mediterranean Regional Office (EMRO): A systematic review and meta-analysis |
title_fullStr | Association between smoking and colorectal cancer in Eastern Mediterranean Regional Office (EMRO): A systematic review and meta-analysis |
title_full_unstemmed | Association between smoking and colorectal cancer in Eastern Mediterranean Regional Office (EMRO): A systematic review and meta-analysis |
title_short | Association between smoking and colorectal cancer in Eastern Mediterranean Regional Office (EMRO): A systematic review and meta-analysis |
title_sort | association between smoking and colorectal cancer in eastern mediterranean regional office (emro): a systematic review and meta-analysis |
topic | Systematic Review/Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445494/ https://www.ncbi.nlm.nih.gov/pubmed/37470665 http://dx.doi.org/10.4103/sjg.sjg_163_23 |
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