Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma

AIM: Ovarian cancer is a serious malignancy with high prevalence and mortality. METHODS: We isolated and characterized an ovarian high-grade serous cancer cell line (M4) from a tumor of a Vietnamese patient with ovarian carcinoma. RESULTS: The M4 cancer cell line showed good proliferation and stabil...

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Autores principales: Linh, Nguyen Thuy, Hang, Ngo Thu, Cuong, Bui Khac, Linh, Dang Thuy, Phuong Linh, Nham Thi, Nguyen-Van, Do, Dzung, Tran Ngoc, Mao, Can Van, Chung, Dang Thanh, Chinh, Le Tri, Hung, Nguyen Phu, Tong, Hoang Van, Toan, Nguyen Linh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445588/
https://www.ncbi.nlm.nih.gov/pubmed/37621847
http://dx.doi.org/10.2144/fsoa-2023-0025
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author Linh, Nguyen Thuy
Hang, Ngo Thu
Cuong, Bui Khac
Linh, Dang Thuy
Phuong Linh, Nham Thi
Nguyen-Van, Do
Dzung, Tran Ngoc
Mao, Can Van
Chung, Dang Thanh
Chinh, Le Tri
Hung, Nguyen Phu
Tong, Hoang Van
Toan, Nguyen Linh
author_facet Linh, Nguyen Thuy
Hang, Ngo Thu
Cuong, Bui Khac
Linh, Dang Thuy
Phuong Linh, Nham Thi
Nguyen-Van, Do
Dzung, Tran Ngoc
Mao, Can Van
Chung, Dang Thanh
Chinh, Le Tri
Hung, Nguyen Phu
Tong, Hoang Van
Toan, Nguyen Linh
author_sort Linh, Nguyen Thuy
collection PubMed
description AIM: Ovarian cancer is a serious malignancy with high prevalence and mortality. METHODS: We isolated and characterized an ovarian high-grade serous cancer cell line (M4) from a tumor of a Vietnamese patient with ovarian carcinoma. RESULTS: The M4 cancer cell line showed good proliferation and stability in culture. Morphologically, the M4 cells showed similar characteristics to tumor cells such as a polyhedral shape, large irregular nuclei, high nuclear/cytoplasmic ratio, high nuclear density and expressing cancer markers like CA125, p53 and Ki67 markers. CONCLUSION: We have successfully isolated and characterized the M4 cell line from a Vietnamese patient with ovarian carcinoma.
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spelling pubmed-104455882023-08-24 Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma Linh, Nguyen Thuy Hang, Ngo Thu Cuong, Bui Khac Linh, Dang Thuy Phuong Linh, Nham Thi Nguyen-Van, Do Dzung, Tran Ngoc Mao, Can Van Chung, Dang Thanh Chinh, Le Tri Hung, Nguyen Phu Tong, Hoang Van Toan, Nguyen Linh Future Sci OA Research Article AIM: Ovarian cancer is a serious malignancy with high prevalence and mortality. METHODS: We isolated and characterized an ovarian high-grade serous cancer cell line (M4) from a tumor of a Vietnamese patient with ovarian carcinoma. RESULTS: The M4 cancer cell line showed good proliferation and stability in culture. Morphologically, the M4 cells showed similar characteristics to tumor cells such as a polyhedral shape, large irregular nuclei, high nuclear/cytoplasmic ratio, high nuclear density and expressing cancer markers like CA125, p53 and Ki67 markers. CONCLUSION: We have successfully isolated and characterized the M4 cell line from a Vietnamese patient with ovarian carcinoma. Future Science Ltd 2023-07-29 /pmc/articles/PMC10445588/ /pubmed/37621847 http://dx.doi.org/10.2144/fsoa-2023-0025 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Article
Linh, Nguyen Thuy
Hang, Ngo Thu
Cuong, Bui Khac
Linh, Dang Thuy
Phuong Linh, Nham Thi
Nguyen-Van, Do
Dzung, Tran Ngoc
Mao, Can Van
Chung, Dang Thanh
Chinh, Le Tri
Hung, Nguyen Phu
Tong, Hoang Van
Toan, Nguyen Linh
Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma
title Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma
title_full Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma
title_fullStr Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma
title_full_unstemmed Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma
title_short Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma
title_sort establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445588/
https://www.ncbi.nlm.nih.gov/pubmed/37621847
http://dx.doi.org/10.2144/fsoa-2023-0025
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