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Sarkosyl differentially solubilizes patient-derived alpha-synuclein fibril strains
Insoluble α-synuclein (αSyn) filaments in brain tissue are a hallmark of Parkinson’s disease (PD) and Multiple system atrophy (MSA), and for structural studies, they have for decades been extracted using the detergent sarkosyl. We asked if PD and MSA patient-derived αSyn filament strains display dif...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445646/ https://www.ncbi.nlm.nih.gov/pubmed/37621995 http://dx.doi.org/10.3389/fmolb.2023.1177556 |