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Sarkosyl differentially solubilizes patient-derived alpha-synuclein fibril strains

Insoluble α-synuclein (αSyn) filaments in brain tissue are a hallmark of Parkinson’s disease (PD) and Multiple system atrophy (MSA), and for structural studies, they have for decades been extracted using the detergent sarkosyl. We asked if PD and MSA patient-derived αSyn filament strains display dif...

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Detalles Bibliográficos
Autores principales:	Gram, Hjalte, Theologidis, Vasileios, Boesen, Thomas, Jensen, Poul Henning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445646/ https://www.ncbi.nlm.nih.gov/pubmed/37621995 http://dx.doi.org/10.3389/fmolb.2023.1177556

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