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An update on the bridging factors connecting autophagy and Nrf2 antioxidant pathway

Macroautophagy/autophagy is a lysosome-dependent catabolic pathway for the degradation of intracellular proteins and organelles. Autophagy dysfunction is related to many diseases, including lysosomal storage diseases, cancer, neurodegenerative diseases, cardiomyopathy, and chronic metabolic diseases...

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Autores principales: Ning, Baike, Hang, Shuqi, Zhang, Wenhe, Mao, Caiwen, Li, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445655/
https://www.ncbi.nlm.nih.gov/pubmed/37621776
http://dx.doi.org/10.3389/fcell.2023.1232241
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author Ning, Baike
Hang, Shuqi
Zhang, Wenhe
Mao, Caiwen
Li, Dan
author_facet Ning, Baike
Hang, Shuqi
Zhang, Wenhe
Mao, Caiwen
Li, Dan
author_sort Ning, Baike
collection PubMed
description Macroautophagy/autophagy is a lysosome-dependent catabolic pathway for the degradation of intracellular proteins and organelles. Autophagy dysfunction is related to many diseases, including lysosomal storage diseases, cancer, neurodegenerative diseases, cardiomyopathy, and chronic metabolic diseases, in which increased reactive oxygen species (ROS) levels are also observed. ROS can randomly oxidize proteins, lipids, and DNA, causing oxidative stress and damage. Cells have developed various antioxidant pathways to reduce excessive ROS and maintain redox homeostasis. Treatment targeting only one aspect of diseases with autophagy dysfunction and oxidative stress shows very limited effects. Herein, identifying the bridging factors that can regulate both autophagy and antioxidant pathways is beneficial for dual-target therapies. This review intends to provide insights into the current identified bridging factors that connect autophagy and Nrf2 antioxidant pathway, as well as their tight interconnection with each other. These factors could be potential dual-purpose targets for the treatment of diseases implicated in both autophagy dysfunction and oxidative stress.
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spelling pubmed-104456552023-08-24 An update on the bridging factors connecting autophagy and Nrf2 antioxidant pathway Ning, Baike Hang, Shuqi Zhang, Wenhe Mao, Caiwen Li, Dan Front Cell Dev Biol Cell and Developmental Biology Macroautophagy/autophagy is a lysosome-dependent catabolic pathway for the degradation of intracellular proteins and organelles. Autophagy dysfunction is related to many diseases, including lysosomal storage diseases, cancer, neurodegenerative diseases, cardiomyopathy, and chronic metabolic diseases, in which increased reactive oxygen species (ROS) levels are also observed. ROS can randomly oxidize proteins, lipids, and DNA, causing oxidative stress and damage. Cells have developed various antioxidant pathways to reduce excessive ROS and maintain redox homeostasis. Treatment targeting only one aspect of diseases with autophagy dysfunction and oxidative stress shows very limited effects. Herein, identifying the bridging factors that can regulate both autophagy and antioxidant pathways is beneficial for dual-target therapies. This review intends to provide insights into the current identified bridging factors that connect autophagy and Nrf2 antioxidant pathway, as well as their tight interconnection with each other. These factors could be potential dual-purpose targets for the treatment of diseases implicated in both autophagy dysfunction and oxidative stress. Frontiers Media S.A. 2023-08-09 /pmc/articles/PMC10445655/ /pubmed/37621776 http://dx.doi.org/10.3389/fcell.2023.1232241 Text en Copyright © 2023 Ning, Hang, Zhang, Mao and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ning, Baike
Hang, Shuqi
Zhang, Wenhe
Mao, Caiwen
Li, Dan
An update on the bridging factors connecting autophagy and Nrf2 antioxidant pathway
title An update on the bridging factors connecting autophagy and Nrf2 antioxidant pathway
title_full An update on the bridging factors connecting autophagy and Nrf2 antioxidant pathway
title_fullStr An update on the bridging factors connecting autophagy and Nrf2 antioxidant pathway
title_full_unstemmed An update on the bridging factors connecting autophagy and Nrf2 antioxidant pathway
title_short An update on the bridging factors connecting autophagy and Nrf2 antioxidant pathway
title_sort update on the bridging factors connecting autophagy and nrf2 antioxidant pathway
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445655/
https://www.ncbi.nlm.nih.gov/pubmed/37621776
http://dx.doi.org/10.3389/fcell.2023.1232241
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