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An LRP1-binding motif in cellular prion protein replicates cell-signaling activities of the full-length protein

Low-density lipoprotein receptor-related protein-1 (LRP1) functions as a receptor for nonpathogenic cellular prion protein (PrP(C)), which is released from cells by ADAM (a disintegrin and metalloproteinase domain) proteases or in extracellular vesicles. This interaction activates cell signaling and...

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Detalles Bibliográficos
Autores principales:	Mantuano, Elisabetta, Zampieri, Carlotta, Azmoon, Pardis, Gunner, Cory B., Heye, Kyle R., Gonias, Steven L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445690/ https://www.ncbi.nlm.nih.gov/pubmed/37368488 http://dx.doi.org/10.1172/jci.insight.170121

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