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Immune responses to Tilapia lake virus infection: what we know and what we don’t know

Tilapia lake virus (TiLV) is a novel contagious pathogen associated with a lethal disease affecting and decimating tilapia populations on several continents across the globe. Fish viral diseases, such as Tilapia lake virus disease (TiLVD), represent a serious threat to tilapia aquaculture. Therefore...

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Autores principales: Kembou-Ringert, Japhette E., Steinhagen, Dieter, Thompson, Kim D., Daly, Janet M., Adamek, Mikolaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445761/
https://www.ncbi.nlm.nih.gov/pubmed/37622112
http://dx.doi.org/10.3389/fimmu.2023.1240094
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author Kembou-Ringert, Japhette E.
Steinhagen, Dieter
Thompson, Kim D.
Daly, Janet M.
Adamek, Mikolaj
author_facet Kembou-Ringert, Japhette E.
Steinhagen, Dieter
Thompson, Kim D.
Daly, Janet M.
Adamek, Mikolaj
author_sort Kembou-Ringert, Japhette E.
collection PubMed
description Tilapia lake virus (TiLV) is a novel contagious pathogen associated with a lethal disease affecting and decimating tilapia populations on several continents across the globe. Fish viral diseases, such as Tilapia lake virus disease (TiLVD), represent a serious threat to tilapia aquaculture. Therefore, a better understanding of the innate immune responses involved in establishing an antiviral state can help shed light on TiLV disease pathogenesis. Moreover, understanding the adaptive immune mechanisms involved in mounting protection against TiLV could greatly assist in the development of vaccination strategies aimed at controlling TiLVD. This review summarizes the current state of knowledge on the immune responses following TiLV infection. After describing the main pathological findings associated with TiLVD, both the innate and adaptive immune responses and mechanisms to TiLV infection are discussed, in both disease infection models and in vitro studies. In addition, our work, highlights research questions, knowledge gaps and research areas in the immunology of TiLV infection where further studies are needed to better understand how disease protection against TiLV is established.
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spelling pubmed-104457612023-08-24 Immune responses to Tilapia lake virus infection: what we know and what we don’t know Kembou-Ringert, Japhette E. Steinhagen, Dieter Thompson, Kim D. Daly, Janet M. Adamek, Mikolaj Front Immunol Immunology Tilapia lake virus (TiLV) is a novel contagious pathogen associated with a lethal disease affecting and decimating tilapia populations on several continents across the globe. Fish viral diseases, such as Tilapia lake virus disease (TiLVD), represent a serious threat to tilapia aquaculture. Therefore, a better understanding of the innate immune responses involved in establishing an antiviral state can help shed light on TiLV disease pathogenesis. Moreover, understanding the adaptive immune mechanisms involved in mounting protection against TiLV could greatly assist in the development of vaccination strategies aimed at controlling TiLVD. This review summarizes the current state of knowledge on the immune responses following TiLV infection. After describing the main pathological findings associated with TiLVD, both the innate and adaptive immune responses and mechanisms to TiLV infection are discussed, in both disease infection models and in vitro studies. In addition, our work, highlights research questions, knowledge gaps and research areas in the immunology of TiLV infection where further studies are needed to better understand how disease protection against TiLV is established. Frontiers Media S.A. 2023-08-09 /pmc/articles/PMC10445761/ /pubmed/37622112 http://dx.doi.org/10.3389/fimmu.2023.1240094 Text en Copyright © 2023 Kembou-Ringert, Steinhagen, Thompson, Daly and Adamek https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kembou-Ringert, Japhette E.
Steinhagen, Dieter
Thompson, Kim D.
Daly, Janet M.
Adamek, Mikolaj
Immune responses to Tilapia lake virus infection: what we know and what we don’t know
title Immune responses to Tilapia lake virus infection: what we know and what we don’t know
title_full Immune responses to Tilapia lake virus infection: what we know and what we don’t know
title_fullStr Immune responses to Tilapia lake virus infection: what we know and what we don’t know
title_full_unstemmed Immune responses to Tilapia lake virus infection: what we know and what we don’t know
title_short Immune responses to Tilapia lake virus infection: what we know and what we don’t know
title_sort immune responses to tilapia lake virus infection: what we know and what we don’t know
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445761/
https://www.ncbi.nlm.nih.gov/pubmed/37622112
http://dx.doi.org/10.3389/fimmu.2023.1240094
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