A CD64/FcγRI-mediated mechanism hijacks PD-1 from PD-L1/2 interaction and enhances anti-PD-1 functional recovery of exhausted T cells

Therapeutic monoclonal antibodies (mAb) targeting the immune checkpoint inhibitor programmed cell death protein 1 (PD-1) have achieved considerable clinical success in anti-cancer therapy through relieving T cell exhaustion. Blockade of PD-1 interaction with its ligands PD-L1 and PD-L2 is an importa...

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Detalles Bibliográficos
Autores principales: Joo, Victor, Petrovas, Constantinos, de Leval, Laurence, Noto, Alessandra, Obeid, Michel, Fenwick, Craig, Pantaleo, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446174/
https://www.ncbi.nlm.nih.gov/pubmed/37622123
http://dx.doi.org/10.3389/fimmu.2023.1213375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446174/
https://www.ncbi.nlm.nih.gov/pubmed/37622123
http://dx.doi.org/10.3389/fimmu.2023.1213375

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