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Amprenavir inhibits pepsin‐mediated laryngeal epithelial disruption and E‐cadherin cleavage in vitro

BACKGROUND: Laryngopharyngeal reflux (LPR) causes chronic cough, throat clearing, hoarseness, and dysphagia and can promote laryngeal carcinogenesis. More than 20% of the US population suffers from LPR and there is no effective medical therapy. Pepsin is a predominant source of damage during LPR whi...

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Detalles Bibliográficos
Autores principales: Samuels, Tina L., Blaine‐Sauer, Simon, Yan, Ke, Johnston, Nikki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446255/
https://www.ncbi.nlm.nih.gov/pubmed/37621274
http://dx.doi.org/10.1002/lio2.1102