The energetics and ion coupling of cholesterol transport through Patched1

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Patched1 (PTCH1) is a tumor suppressor protein of the mammalian Hedgehog (HH) signaling pathway, implicated in embryogenesis and tissue homeostasis. PTCH1 inhibits the G protein–coupled receptor Smoothened (SMO) via a debated mechanism involving modulating ciliary cholesterol accessibility. Using ex...

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Detalles Bibliográficos
Autores principales: Ansell, T. Bertie, Corey, Robin A., Viti, Lucrezia Vittoria, Kinnebrew, Maia, Rohatgi, Rajat, Siebold, Christian, Sansom, Mark S. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446486/
https://www.ncbi.nlm.nih.gov/pubmed/37611095
http://dx.doi.org/10.1126/sciadv.adh1609
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