A MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN-amplified neuroblastoma

MYCN amplification (MNA) is a defining feature of high-risk neuroblastoma (NB) and predicts poor prognosis. However, whether genes within or in close proximity to the MYCN amplicon also contribute to MNA(+) NB remains poorly understood. Here, we identify that GREB1, a transcription factor encoding g...

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Detalles Bibliográficos
Autores principales: Zhang, Hai-Feng, Delaidelli, Alberto, Javed, Sumreen, Turgu, Busra, Morrison, Taylor, Hughes, Christopher S., Yang, Xiaqiu, Pachva, Manideep, Lizardo, Michael M., Singh, Gurdeep, Hoffmann, Jennifer, Huang, Yue Zhou, Patel, Khushbu, Shraim, Rawan, Kung, Sonia H. Y., Morin, Gregg B., Aparicio, Samuel, Martinez, Daniel, Maris, John M., Bosse, Kristopher R., Williams, Karla C., Sorensen, Poul H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446492/
https://www.ncbi.nlm.nih.gov/pubmed/37611092
http://dx.doi.org/10.1126/sciadv.adg6693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446492/
https://www.ncbi.nlm.nih.gov/pubmed/37611092
http://dx.doi.org/10.1126/sciadv.adg6693

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