An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming

Advanced strategies to interconvert cell types provide promising avenues to model cellular pathologies and to develop therapies for neurological disorders. Yet, methods to directly transdifferentiate somatic cells into multipotent induced neural stem cells (iNSCs) are slow and inefficient, and it is...

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Detalles Bibliográficos
Autores principales: Weng, Mingxi, Hu, Haoqing, Graus, Matthew S., Tan, Daisylyn Senna, Gao, Ya, Ren, Shimiao, Ho, Derek Hoi Hang, Langer, Jakob, Holzner, Markus, Huang, Yuhua, Ling, Guang Sheng, Lai, Cora Sau Wan, Francois, Mathias, Jauch, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446497/
https://www.ncbi.nlm.nih.gov/pubmed/37611093
http://dx.doi.org/10.1126/sciadv.adh2501

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