Gemcitabine enhances pharmacokinetic exposure of the major components of Danggui Buxue Decoction in rat via the promotion of intestinal permeability and down-regulation of CYP3A for combination treatment of non-small cell lung cancer

CONTEXT: Danggui Buxue Decoction (DBD), a traditional Chinese medicine formula, has the potential to enhance the antitumor effect of gemcitabine in non-small cell lung cancer (NSCLC) treatment by increasing gemcitabine’s active metabolites. However, whether gemcitabine affects the pharmacokinetics o...

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Detalles Bibliográficos
Autores principales: Xu, Xin, Sun, Xi-yang, Chang, Ming, Hu, Zhao-liang, Cheng, Ting-ting, Hang, Tai-jun, Song, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446811/
https://www.ncbi.nlm.nih.gov/pubmed/37606265
http://dx.doi.org/10.1080/13880209.2023.2246500

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