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Polyvinyl alcohol-citrate-stabilized silver nanoparticles as an optical sensor for selective colorimetric determination of sildenafil
A facile and sensitive colorimetric detection method for sildenafil citrate (SLDC) has been developed by using polyvinyl alcohol-citrate-stabilized silver nanoparticles (PVA-Cit-AgNPs). The sensitivity and selectivity of colorimetric detection were investigated in detail. The PVA-Cit-AgNPs could be...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Scientific and Technological Research Council of Turkey (TUBITAK)
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446920/ https://www.ncbi.nlm.nih.gov/pubmed/37621342 http://dx.doi.org/10.55730/1300-0527.3499 |
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author | AVAN, Asiye Aslıhan |
author_facet | AVAN, Asiye Aslıhan |
author_sort | AVAN, Asiye Aslıhan |
collection | PubMed |
description | A facile and sensitive colorimetric detection method for sildenafil citrate (SLDC) has been developed by using polyvinyl alcohol-citrate-stabilized silver nanoparticles (PVA-Cit-AgNPs). The sensitivity and selectivity of colorimetric detection were investigated in detail. The PVA-Cit-AgNPs could be induced to aggregate immediately in the presence of SLDC, especially after the addition of 0.1 M HCl solution. The SLD could be detected by the colorimetric response of AgNPs that could be monitored by a UV–Vis spectrophotometer or even the naked eye. The linear range was found to be 0.6–5.0 μM with the calculated detection limit of 0.1 μM and the naked-eye detection limit was determined as low as 0.6 μM. The proposed method is successfully employed for the determination of SLDC in commercially available tablets. Meanwhile, the excipients present in the pharmaceuticals do not interfere with the assay procedure. |
format | Online Article Text |
id | pubmed-10446920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Scientific and Technological Research Council of Turkey (TUBITAK) |
record_format | MEDLINE/PubMed |
spelling | pubmed-104469202023-08-24 Polyvinyl alcohol-citrate-stabilized silver nanoparticles as an optical sensor for selective colorimetric determination of sildenafil AVAN, Asiye Aslıhan Turk J Chem Research Article A facile and sensitive colorimetric detection method for sildenafil citrate (SLDC) has been developed by using polyvinyl alcohol-citrate-stabilized silver nanoparticles (PVA-Cit-AgNPs). The sensitivity and selectivity of colorimetric detection were investigated in detail. The PVA-Cit-AgNPs could be induced to aggregate immediately in the presence of SLDC, especially after the addition of 0.1 M HCl solution. The SLD could be detected by the colorimetric response of AgNPs that could be monitored by a UV–Vis spectrophotometer or even the naked eye. The linear range was found to be 0.6–5.0 μM with the calculated detection limit of 0.1 μM and the naked-eye detection limit was determined as low as 0.6 μM. The proposed method is successfully employed for the determination of SLDC in commercially available tablets. Meanwhile, the excipients present in the pharmaceuticals do not interfere with the assay procedure. Scientific and Technological Research Council of Turkey (TUBITAK) 2022-09-20 /pmc/articles/PMC10446920/ /pubmed/37621342 http://dx.doi.org/10.55730/1300-0527.3499 Text en © TÜBİTAK https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Research Article AVAN, Asiye Aslıhan Polyvinyl alcohol-citrate-stabilized silver nanoparticles as an optical sensor for selective colorimetric determination of sildenafil |
title | Polyvinyl alcohol-citrate-stabilized silver nanoparticles as an optical sensor for selective colorimetric determination of sildenafil |
title_full | Polyvinyl alcohol-citrate-stabilized silver nanoparticles as an optical sensor for selective colorimetric determination of sildenafil |
title_fullStr | Polyvinyl alcohol-citrate-stabilized silver nanoparticles as an optical sensor for selective colorimetric determination of sildenafil |
title_full_unstemmed | Polyvinyl alcohol-citrate-stabilized silver nanoparticles as an optical sensor for selective colorimetric determination of sildenafil |
title_short | Polyvinyl alcohol-citrate-stabilized silver nanoparticles as an optical sensor for selective colorimetric determination of sildenafil |
title_sort | polyvinyl alcohol-citrate-stabilized silver nanoparticles as an optical sensor for selective colorimetric determination of sildenafil |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10446920/ https://www.ncbi.nlm.nih.gov/pubmed/37621342 http://dx.doi.org/10.55730/1300-0527.3499 |
work_keys_str_mv | AT avanasiyeaslıhan polyvinylalcoholcitratestabilizedsilvernanoparticlesasanopticalsensorforselectivecolorimetricdeterminationofsildenafil |