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Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review

Chromophobe renal cell carcinoma (CRCC) is a subtype of renal cell carcinoma (RCC) with a favorable prognosis. Sarcomatoid differentiation in RCC is assumed to be the outcome of the parent tumor’s dedifferentiation and associated with poorer prognosis. Sarcomatoid differentiation can be detected in...

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Autores principales: Abuorouq, Saleh, Sahawneh, Firas, Halalsheh, Omar, Haddad, Husam K, Mekail, Raed, Alzoubi, Hiba, Alrjoub, Mo’ath, Serhan, Hashem A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447077/
https://www.ncbi.nlm.nih.gov/pubmed/37621958
http://dx.doi.org/10.1093/jscr/rjad476
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author Abuorouq, Saleh
Sahawneh, Firas
Halalsheh, Omar
Haddad, Husam K
Mekail, Raed
Alzoubi, Hiba
Alrjoub, Mo’ath
Serhan, Hashem A
author_facet Abuorouq, Saleh
Sahawneh, Firas
Halalsheh, Omar
Haddad, Husam K
Mekail, Raed
Alzoubi, Hiba
Alrjoub, Mo’ath
Serhan, Hashem A
author_sort Abuorouq, Saleh
collection PubMed
description Chromophobe renal cell carcinoma (CRCC) is a subtype of renal cell carcinoma (RCC) with a favorable prognosis. Sarcomatoid differentiation in RCC is assumed to be the outcome of the parent tumor’s dedifferentiation and associated with poorer prognosis. Sarcomatoid differentiation can be detected in CRCC as well as other subtypes, but the occurrence of divergent osteosarcoma-like components in sarcomatoid CRCC is extremely unusual. Only six cases have been previously reported in the literature, we reviewed them and presented the seventh case in a 71-year-old male who had a left kidney heterogeneous mass. The resected tumor showed a sarcoma-like spindle cell area with an adjacent osteosarcoma area producing lacy bone material and bony trabeculae in a hard area mixed with a typical CRCC. In conclusion, sarcomatoid CRCC with osteosarcomatous differentiation is a very rare tumor and should be kept in mind especially when dealing with small or frozen sections biopsies.
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spelling pubmed-104470772023-08-24 Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review Abuorouq, Saleh Sahawneh, Firas Halalsheh, Omar Haddad, Husam K Mekail, Raed Alzoubi, Hiba Alrjoub, Mo’ath Serhan, Hashem A J Surg Case Rep Case Series Chromophobe renal cell carcinoma (CRCC) is a subtype of renal cell carcinoma (RCC) with a favorable prognosis. Sarcomatoid differentiation in RCC is assumed to be the outcome of the parent tumor’s dedifferentiation and associated with poorer prognosis. Sarcomatoid differentiation can be detected in CRCC as well as other subtypes, but the occurrence of divergent osteosarcoma-like components in sarcomatoid CRCC is extremely unusual. Only six cases have been previously reported in the literature, we reviewed them and presented the seventh case in a 71-year-old male who had a left kidney heterogeneous mass. The resected tumor showed a sarcoma-like spindle cell area with an adjacent osteosarcoma area producing lacy bone material and bony trabeculae in a hard area mixed with a typical CRCC. In conclusion, sarcomatoid CRCC with osteosarcomatous differentiation is a very rare tumor and should be kept in mind especially when dealing with small or frozen sections biopsies. Oxford University Press 2023-08-23 /pmc/articles/PMC10447077/ /pubmed/37621958 http://dx.doi.org/10.1093/jscr/rjad476 Text en Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2023. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Series
Abuorouq, Saleh
Sahawneh, Firas
Halalsheh, Omar
Haddad, Husam K
Mekail, Raed
Alzoubi, Hiba
Alrjoub, Mo’ath
Serhan, Hashem A
Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review
title Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review
title_full Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review
title_fullStr Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review
title_full_unstemmed Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review
title_short Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review
title_sort chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447077/
https://www.ncbi.nlm.nih.gov/pubmed/37621958
http://dx.doi.org/10.1093/jscr/rjad476
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