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Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review
Chromophobe renal cell carcinoma (CRCC) is a subtype of renal cell carcinoma (RCC) with a favorable prognosis. Sarcomatoid differentiation in RCC is assumed to be the outcome of the parent tumor’s dedifferentiation and associated with poorer prognosis. Sarcomatoid differentiation can be detected in...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447077/ https://www.ncbi.nlm.nih.gov/pubmed/37621958 http://dx.doi.org/10.1093/jscr/rjad476 |
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author | Abuorouq, Saleh Sahawneh, Firas Halalsheh, Omar Haddad, Husam K Mekail, Raed Alzoubi, Hiba Alrjoub, Mo’ath Serhan, Hashem A |
author_facet | Abuorouq, Saleh Sahawneh, Firas Halalsheh, Omar Haddad, Husam K Mekail, Raed Alzoubi, Hiba Alrjoub, Mo’ath Serhan, Hashem A |
author_sort | Abuorouq, Saleh |
collection | PubMed |
description | Chromophobe renal cell carcinoma (CRCC) is a subtype of renal cell carcinoma (RCC) with a favorable prognosis. Sarcomatoid differentiation in RCC is assumed to be the outcome of the parent tumor’s dedifferentiation and associated with poorer prognosis. Sarcomatoid differentiation can be detected in CRCC as well as other subtypes, but the occurrence of divergent osteosarcoma-like components in sarcomatoid CRCC is extremely unusual. Only six cases have been previously reported in the literature, we reviewed them and presented the seventh case in a 71-year-old male who had a left kidney heterogeneous mass. The resected tumor showed a sarcoma-like spindle cell area with an adjacent osteosarcoma area producing lacy bone material and bony trabeculae in a hard area mixed with a typical CRCC. In conclusion, sarcomatoid CRCC with osteosarcomatous differentiation is a very rare tumor and should be kept in mind especially when dealing with small or frozen sections biopsies. |
format | Online Article Text |
id | pubmed-10447077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-104470772023-08-24 Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review Abuorouq, Saleh Sahawneh, Firas Halalsheh, Omar Haddad, Husam K Mekail, Raed Alzoubi, Hiba Alrjoub, Mo’ath Serhan, Hashem A J Surg Case Rep Case Series Chromophobe renal cell carcinoma (CRCC) is a subtype of renal cell carcinoma (RCC) with a favorable prognosis. Sarcomatoid differentiation in RCC is assumed to be the outcome of the parent tumor’s dedifferentiation and associated with poorer prognosis. Sarcomatoid differentiation can be detected in CRCC as well as other subtypes, but the occurrence of divergent osteosarcoma-like components in sarcomatoid CRCC is extremely unusual. Only six cases have been previously reported in the literature, we reviewed them and presented the seventh case in a 71-year-old male who had a left kidney heterogeneous mass. The resected tumor showed a sarcoma-like spindle cell area with an adjacent osteosarcoma area producing lacy bone material and bony trabeculae in a hard area mixed with a typical CRCC. In conclusion, sarcomatoid CRCC with osteosarcomatous differentiation is a very rare tumor and should be kept in mind especially when dealing with small or frozen sections biopsies. Oxford University Press 2023-08-23 /pmc/articles/PMC10447077/ /pubmed/37621958 http://dx.doi.org/10.1093/jscr/rjad476 Text en Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2023. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Series Abuorouq, Saleh Sahawneh, Firas Halalsheh, Omar Haddad, Husam K Mekail, Raed Alzoubi, Hiba Alrjoub, Mo’ath Serhan, Hashem A Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review |
title | Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review |
title_full | Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review |
title_fullStr | Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review |
title_full_unstemmed | Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review |
title_short | Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review |
title_sort | chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447077/ https://www.ncbi.nlm.nih.gov/pubmed/37621958 http://dx.doi.org/10.1093/jscr/rjad476 |
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